Comparison of Respiratory muscle strength in Chronic heart failure patients and age, gender matched healthy controls – A Comparative study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- Maximum Inspiratory Pressure and Maximum Expiratory Pressure
研究概览
简要总结
Heart failure is a common reason for hospitalization and is associated with high health care costs and high symptom burden. In 2021, there were 56.5 million (95% Uncertainty Interval (UI): 49.7 million to 63.7 million) prevalent cases of heart failure globally. Heart failure is a highly prevalent condition, particularly in older age groups. The aim of the study was to compare the respiratory muscle strength in chronic heart failure patients and age, gender matched healthy controls. 43 chronic heart failure patients and 43 age and gender matched healthy controls were included in the study. MIP and MEP were used as outcome measures to assess respiratory muscle strength using a micro-RPM device. Statistically significant reductions were found in Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP) in Chronic heart failure patients (Group A) as compared to Age, gender matched healthy controls (Group B). Thus, the study concluded that there was a significant reduction in respiratory muscle strength in chronic heart failure patients as compared to age, gender matched healthy controls.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Study Group
- •Chronic heart failure patients for more than 3 months and NYHA grade 1 and 2 on OPD basis.
- •LVEF less than 40%.
- •Control Group
- •Age and gender matched healthy individuals.
排除标准
- •Study Group
- •Hospitalization history of more than a week within past 3 months.
- •Any cardiac surgery within past 6 months.
- •Class 3 and 4 angina pectoris on NYHA scale.
- •Recent STEMI or Acute coronary syndrome NSTEMI.
- •Complex arrhythmias.
- •Patients with conduction blocks (Grade 1,2,3).
- •Uncontrolled hypertension with systolic BP more than 140 mm Hg and diastolic BP more than 90 mm Hg and resting heart rate more than 100 beats per min.
- •Patients receiving corticosteroids, hormones or any other chemotherapy treatment.
- •History of smoking.
- •Control Group 1.
结局指标
主要结局
Maximum Inspiratory Pressure and Maximum Expiratory Pressure
时间窗: 06 months
次要结局
- Not Applicable(Not Applicable)
研究者
Dr Rachna Arora
Topiwala National Medical College and Dr B.Y.L. Charitable Hospital