Impact of dexmedetomidine supplemented analgesia on postoperative delirium and long-term survival in elderly patients after cancer surgery: A multicenter, double-blinded, randomized controlled trial

Hirota Kazuyoshi0 个研究点目标入组 0 人开始时间: 2020年8月13日最近更新: 2023年10月17日

试验速览

one

•1 Age older than 65 years, less than 90 years
•2 Scheduled to undergo surgery for primary solid organ cancer under general anesthesia, with an expected duration of surgery longer than 2 hours
•3 Planned to use patient-controlled intravenous analgesia (PCIA) after surgery
•4 Provide written informed consent.

•Patients who meet any of the following criteria will be excluded.
•1 Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis;
•2 Preoperative radio- or chemotherapy;
•3 Inability to communicate in the preoperative period because of coma, profound dementia or language barrier;
•4 Preoperative obstructive sleep apnea (previously diagnosed as obstructive sleep apnea, or STOP-Bang scoring model score
•5 Brain injury or neurosurgery;
•6 Preoperative left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker;
•7 Severe hepatic dysfunction (Child-Pugh class C) or severe renal dysfunction (requirement of renal replacement therapy before surgery);
•8 ASA classification IV or above.

发起方

Hirota Kazuyoshi