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Clinical Trials/NCT06432335
NCT06432335
Not yet recruiting
Not Applicable

E-Socket, Diagnostic Monitoring

University of Washington0 sites30 target enrollmentJuly 1, 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Trans-Tibial Amputation
Sponsor
University of Washington
Enrollment
30
Primary Endpoint
Anterior-Distal Limb Motion
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

The long-term goal of this research is a socket-embedded prosthesis use and socket fit monitor (E-Socket) that facilitates clinical decision-making in the diagnosis and prognosis of health issues faced by people with transtibial amputation. The overall strategy is to enhance the E-socket to include additional metrics that we identified needed from studies to date (Aim #1). Then we conduct a randomized control trial testing the diagnostic utility of the E-socket data in clinical care (Aim #2). From the data collected in that study, we develop the prognostic capability of the system (Aim #3).

Aim 3 will not involve human subject testing as it will focus on the development of the system in preparation for a future aim involving participants' own clinicians.

Note: we use the term "diagnostic" throughout our application in a general sense. The device will not be diagnosing specific diseases or medical conditions.

Registry
clinicaltrials.gov
Start Date
July 1, 2025
End Date
June 30, 2030
Last Updated
last year
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Joan E Sanders

Associate Professor

University of Washington

Eligibility Criteria

Inclusion Criteria

  • Prosthesis Users:
  • Aims 1 and 2
  • Over 18 years of age
  • Unilateral or bilateral trans-tibial amputation at least 12 months prior
  • Have a limb of length 9 cm or greater
  • Are capable of at least 5 minutes of continuous walking
  • Regularly use a definitive prosthesis
  • Do not regularly use assistive devices (e.g., cane, walker) for ambulation
  • Do not have open wounds on their residual limb at the time of enrollment
  • Regularly visit their prosthetist at least twice a year,

Exclusion Criteria

  • Prosthesis Users:
  • Aims 1 and 2
  • Reduced skin sensation
  • Presence of skin breakdown
  • Regular use of an assistive device
  • Persons with trans-femoral amputation
  • Vacuum suspension users

Outcomes

Primary Outcomes

Anterior-Distal Limb Motion

Time Frame: 12 months

Monitor anterior-distal limb motion in the prosthesis to determine if limb motions and activity changes precede changes in limb health. Interviews with the participants and questionnaires will be used to assess the outcome measure.

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