Juvenile Inflammatory Rheumatism (JIR) Cohorte

• Conditions: Arthritis, Juvenile Rheumatoid

• Registration Number: NCT02377245
• Lead Sponsor: Michaël Hofer

Brief Summary

The investigators created a cohort of patients with juvenile inflammatory rheumatisms with the purpose to follow them prospectively, and investigate the tolerance and efficacy of immunosuppresive and biological agents.

Detailed Description

The JIR-cohort has to be filled by an authorized investigator during or after the consultation. Each patient much be followed at least once a year.

Different data are requested in the JIR-cohort: diagnosis, treatment, adverse events and outcome.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-10-09
• Study First Submitted QC: 2015-02-24
• Study First Posted: 2015-03-03
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-12
• Last Update Posted: 2023-06-15
• Primary Completion: 2028-12
• Study Completion: 2030-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 15000

Inclusion Criteria

• Patients with juvenile inflammatory diseases
• Age at onset up to 18 years old
• Consent according national codes of ethics and current laws

Exclusion Criteria

• Non-consent from patients and/or legal representative

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of treatments prescribed off label	10 Years
Length in months of drug survival in patient treated with at least two consecutive biological agents	10 Years
Number of severe and very severe adverse event as a mesure of safety and tolerability	10 years

Trial Locations

Locations (45)

Kinderspital Basel; 🇨🇭 Basel, Switzerland

Hôpital Reine Fabiola; 🇧🇪 Bruxelles, Belgium

UZ Leuven; 🇧🇪 Leuven, Belgium

CHU Charleroi; 🇧🇪 Charleroi, Belgium

CHR Citadelle; 🇧🇪 Liège, Belgium

CHC Liège; 🇧🇪 Liège, Belgium

CHU Belfort; 🇫🇷 Belfort, France

CHRU Besançon; 🇫🇷 Besançon, France

Hôpital Pellegrin enfants; 🇫🇷 Bordeaux, France

CHRU Brest; 🇫🇷 Brest, France

CHU de Grenoble; 🇫🇷 Grenoble, France

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France

Hôpital Femme Mère Enfant; 🇫🇷 Bron, France

Hôpital Bicêtre; 🇫🇷 Le Kremlin Bicêtre, France

CHRU Lille; 🇫🇷 Lille, France

CHU Arnaud de Villeneuve; 🇫🇷 Montpellier, France

CHU Nantes; 🇫🇷 Nantes, France

Hôpital Nord Marseille; 🇫🇷 Marseille, France

Centre hospitalier de Mulhouse; 🇫🇷 Mulhouse, France

Hôpital necker Enfants Malade; 🇫🇷 Paris, France

Hôpital Robert Debré; 🇫🇷 Paris, France

CHU St-Etienne; 🇫🇷 St-Etienne, France

CHU Nimes; 🇫🇷 Nimes, France

Nice CHU - Lenval; 🇫🇷 Nice, France

Hôpital Tenon; 🇫🇷 Paris, France

CHU Tours; 🇫🇷 Tours, France

CHU Rennes; 🇫🇷 Rennes, France

University Hospital Muenster; 🇩🇪 Münster, Germany

Hôpital des enfants; 🇫🇷 Toulouse, France

Hôpital de Hautepierre; 🇫🇷 Strasbourg, France

CHUV; 🇨🇭 Lausanne, Vaud, Switzerland

Hôpital Ibnou Rochd; 🇲🇦 Casablanca, Morocco

Kantonsspital Aarau; 🇨🇭 Aarau, Switzerland

Universitäts-Augenklinik Basel; 🇨🇭 Basel, Switzerland

Kantonspital Graubunden; 🇨🇭 Chur, Switzerland

Ospedale Regionale di Bellinzona e valli; 🇨🇭 Bellinzona, Switzerland

Klinik für Rheumatologie und internistische Rehabilitation; 🇨🇭 Valens, Switzerland

Kinderspital Luzern; 🇨🇭 Luzern, Switzerland

Hôpital Ophtalmique; 🇨🇭 Lausanne, Switzerland

Kantonspital Winterthur; 🇨🇭 Winterthur, Switzerland

Ostschweizer Kinderspital St-Gallen; 🇨🇭 St-Gallen, Switzerland

Kinderspital Zürich; 🇨🇭 Zürich, Switzerland

Hôpital André Mignot; 🇫🇷 Versailles, France

CHU Reims; 🇫🇷 Reims, France

Ospedale Regionale di Lugano; 🇨🇭 Lugano, Switzerland