The effects of melatonin supplementation in the treatment of rheumatoid arthritis
Phase 3
- Conditions
- Rheumatoid arthritis.Rheumatoid arthritis with rheumatoid factor
- Registration Number
- IRCT20170513033941N67
- Lead Sponsor
- Vice chancellor for research, Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
Patients diagnosed with rheumatoid arthritis
Individuals aged 20-80 years old
Exclusion Criteria
Patients with infectious, malignant and other inflammatory diseases
those taking melatonin supplements or antioxidant supplements within 3 months prior to enrollment in the study
the night shift workers
subjects taking antibiotics medications
unwillingness to cooperate
Patients with thyroid diseases
Current smokers
Rheumatoid arthritis patients who were diagnosed less than on 1 year before the start of the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CRP. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Qualitative (Negative, +1, +2 and +3).;ESR. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: mm/h.;Disease activity. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: DAS28-ESR (using a questionnaire for VAS and a checklist to note physical examination results).
- Secondary Outcome Measures
Name Time Method