EFFECTIVENESS OF SYSTEMIC ADMINISTRATION OF 4 diffrent antibiotics IN CHRONIC PERIODONTITIS - A RANDOMISED CONTROLLED CLINICAL TRIAL
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- bleeding on probing
研究概览
简要总结
Chronic periodontitis, a prevalent inflammatory condition affecting periodontal tissues, necessitates multifaceted therapeutic approaches. While mechanical debridement remains fundamental, the adjunctive use of systemic antibiotics has garnered attention for its potential to enhance treatment outcomes. This randomized controlled clinical trial addresses a critical knowledge gap by systematically evaluating the effectiveness of four antibiotic regimens: amoxicillin and metronidazole, doxycycline, azithromycin, and amoxicillin alone in the management of chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Day(s) 至 50.00 Day(s)（—）
- 性别
- All
入选标准
- •Adults aged from 18 years to 50 years.
- •Stage ∣ and Stage ∥ periodontitis based on criteria established by the American Academy of Periodontology.
- •Presence of at least 6 teeth with probing depth ≥ [4 mm] and clinical attachment loss ≥ [2 mm].
排除标准
- •History of systemic antibiotic use within the past [3 months].
- •Pregnant or lactating individuals.
- •Known allergies to the study antibiotics.
- •Severe systemic diseases affecting periodontal health.
结局指标
主要结局
bleeding on probing
时间窗: baseline, 2 weeks and 1 month
pocket depth
时间窗: baseline, 2 weeks and 1 month
clinical attachment levels
时间窗: baseline, 2 weeks and 1 month
次要结局
- plaque index(gingival index)
研究者
vazeeha afrin syed
saveetha dental college and hospital,SIMATS UNIVERSITY