Effect of treatment with whole Grape Juice along with traditional treatment in patients hospitalized with covid19

Phase 1

• Conditions: Inflammation; Oxidative Stress; Muscle Strength; C01.748.214

• Registration Number: RBR-4bcp54k
• Lead Sponsor: Empresa Brasileira de Serviços Hospitalares

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-08-17
• Study Start: 2021-09-06
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Volunteers of both sexes over 18 years of age who had confirmed COVID-19 disease between October 20, 2020 and February 28, 2021, and who were functionally able to ingest food, in addition to agreeing to participate in the study by signing the Informed Consent Form

Exclusion Criteria

Patients who had difficulties in ingesting food during the study, died and/or did not undergo the final tests at hospital discharge, in addition to medical recommendations not to ingest the drink, were excluded from the study.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to find a clinical improvement in patients hospitalized with covid 19 who were supplemented with whole red grape juice, verified by a decrease in systemic inflammation with a reduction in the inflammatory marker PRC (C-reactive protein) and a reduction in oxidant markers.;A decrease in the inflammatory marker CRP (C-reactive protein) was observed in both groups. In the Control Group a reduction of 33.81% was observed, however, in the Grape Juice Group the reduction was 71.64%. There was a small increase in the oxidative marker MPO (myeloperoxidase)

Secondary Outcome Measures

Name	Time	Method
It is expected that, with the reduction of inflammatory and oxidative stress markers, there will be a clinical improvement in hospitalized patients, and, therefore, there will be a decrease in the hospitalization time of these patients;There was a much greater reduction in the inflammatory marker CRP (C-reactive protein) in the grape juice group, causing a shorter hospital stay in these patients around 6.85 days, while the control group remained hospitalized around 9.94 days