Pilot study on the effect of mechanical stimulation of bone on ATP release in humans in vivo

Completed

• Conditions: bone fragility; osteoporosis; 10005959

• Registration Number: NL-OMON34857
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Healthy human volunteers;
- Age 18-35 years;
- Cannulation of veins in forearm possible.

Exclusion Criteria

- Metabolic bone disease (osteoporosis, Paget's disease, hyperparathyroidism, osteomalacia) or any other condition affecting bone metabolism (e.g. corticoid-treated rheumatoid arthritis);
- Recent bone fracture of any kind <= 12 months preceding the study.
- Blood donors.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>As the primary outcome parameter, a change in extracellular ATP concentrations<br /><br>following the mechanical intervention will be assessed systemically. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.a.</p><br>