Clinical (BMI & MRI) and Biochemical (Adiponectin, Leptin, TNF-α & IL-6) Effects of High-intensity Aerobic Training With a High Protein Diet in Children With Obesity Following COVID-19 Infection.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pediatric Obesity
- Sponsor
- Prince Sattam Bin Abdulaziz University
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- Body mass index (BMI)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The coronavirus disease (COVID-19), is a communicable pandemic disease as stated by the world health organization (WHO), which has been affecting the world since December 2019. COVID-19 infected children develop the signs and symptoms of the disease, which can be exaggerated or life-threatening when associated with comorbidities like; obesity, sickle cell anemia, immune disorders, chromosomal abnormalities, chronic respiratory or cardiac problems, and congenital malformations.3 It is observed that children affected with COVID-19 who are physically inactive or in a sedentary lifestyle may induce and develop obesity. It is a major health concern in this pandemic situation, which can be addressed and treated with the use of appropriate physical training and proper dietary habits.
Detailed Description
Children confirmed with COVID-19 infection have some systemic illness, that might lead to children with obesity. They are advised to perform regular physical training and consume a proper diet to prevent and treat negative consequences. Therefore, different obesity management and weight reduction protocols are developed to control and prevent health problems and socio-economic issues associated with obesity. The management of this clinical condition has received very little attention, there is no well-defined exercise protocols or dietary prescription for this special population; therefore, there is a need for an elaborative trial in this field. Hence, the aim of this trial was to investigate and compare the clinical and psychological effects of integrated physical training with a high protein diet versus a low protein diet in community-dwelling COVID-19 infected children with obesity.
Investigators
Gopal Nambi
Associate Professor
Prince Sattam Bin Abdulaziz University
Eligibility Criteria
Inclusion Criteria
- •Positively diagnosed COVID-19 children
- •age group of 5 - 12 years
- •Body mass index (BMI) between 85th to 99th percentiles
Exclusion Criteria
- •history of physical training,
- •taking medications,
- •recent surgeries,
- •fractures and joint problems in the lower extremity,
- •cardiac and respiratory problems,
- •neurological issues,
- •major psychiatric problems,
- •other systemic diseases,
- •contraindications for physical training and family with food restrictions
Outcomes
Primary Outcomes
Body mass index (BMI)
Time Frame: 6 months
For children, age adjusted BMI percentile (BMI %) was calculated, which is a reliable and valid measurement to measure the stage of obesity.
Secondary Outcomes
- Muscle cross sectional area - CSA(6 months.)
- Adiponectin(6 months)
- Leptin(6 months)
- TNF-α(6 months.)
- IL-6(6 months.)