Use of pulmonary arterial velocity time integral variation and effect of inspiratory pause in predicting fluid responsiveness in acute circulatory failure
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- To evaluate the correlation between pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.
研究概览
简要总结
Fluidadministration is the first-line therapy in patients with acute circulatoryfailure. Except in cases of cardiogenic shock, fluid depletionor hypovolemia is the primary cause of acute circulatory failure. Hence fluidresuscitation is essential in the early phases of shock, particularly in casesof sepsis. In our prospectiveobservational study, we plan to compare pulmonary arterial velocity time integral variation, Aortic velocity timeintegral variation and inspiratory pause maneuver to predict fluidresponsiveness in mechanically ventilated, acute circulatory failure patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Mechanically ventilated patients of age 18 years and more admitted in the ICU.
- •2.Patients with Acute circulatory failure – presence of any one of the following.
- •Systolic blood pressure <90 mm Hg or MAP < 65 mmHg -Need of vasopressors to maintain systolic blood pressure > 90 mmHg. -Urine output < 0.5ml/kg/hour for 2 hours -Heart rate > 100 /min.
排除标准
- •Patients not in sinus rhythm Patients with low tidal volumes (less than 6 ml/kg) Patients with known cardiac valvular dysfunction Right heart failure Patients with very high respiratory rate (HR/RR <3.6) Morbid obesity-BMI ≥35 kg/m2 Poor echocardiographic window.
结局指标
主要结局
To evaluate the correlation between pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.
时间窗: 1 day
次要结局
- To determine sensitivity, specificity, positive predictive value and negative predictive value of pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.(1 day)