Lyon Initiative for the Mobile Demedicalized Initiation of Lung Cancer Screening
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 4,312
- 试验地点
- 2
- 主要终点
- Proportion of socially deprived participants included in the mobile screening group
研究概览
简要总结
Lung cancer screening using low-dose CT (LDCT) has been shown to reduce mortality in high-risk populations. In 2022, the French National Cancer Institute (INCa) issued guidelines recommending screening for individuals aged 50-74 with a history of heavy smoking, including current smokers or those who quit less than 15 years ago. A national pilot program (IMPULSION) will be launched in 2025.
Lung cancer incidence is strongly correlated with socioeconomic status, yet underserved populations remain difficult to engage in screening programs. Mobile health units using a "reach-out" strategy have demonstrated effectiveness in other countries (UK, Brazil, USA). In France, this approach has been used for breast cancer screening via mobile mammography units.
The MobILYAD project aims to compare two screening modalities- a mobile demedicalized unit (CT-equipped van with trained nurses) and a conventional hospital-based unit- to assess the effectiveness of mobile screening in reaching socially disadvantaged populations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Proportion of socially deprived participants included in the mobile screening group
时间窗: Baseline (Day 0)
The percentage of participants with an EPICES score ≥ 4 (indicating social vulnerability) in the mobile screening arm, compared to the non-mobile arm.
次要结局
- Rate of positive screening(Up to 3 months post-initial CT)
- Lung cancer incidence(Over 12 months)
- COPD detection relevance(Baseline and 12 months)
- Cardiovascular risk detection relevance(Baseline and 12 months)
- Creation of biobank (Bio-ILYAD)(At inclusion)
- Lung cancer staging(Within 12 months)
- Histological type of diagnosed lung cancers(Within 12 month)
- Initial treatment of diagnosed lung cancers(Within 3 months of diagnosis)
- Participation by socio-demographic profile(Inclusion)
- Mobile feasibility(Throughout inclusion period)
- Feasibility of task-shifting to nurses(Throughout inclusion period)
- Adherence to intermediate CT scans(Month 1, Month 3, Month 6 if clinically indicated)
- Adherence to 12-month CT scan(At Month 12)
- Adherence to tobacco cessation consultations(Over 12 months)
- Smoking cessation success(At 12 months)