Effectiveness of Apneic Oxygenation Using High-flow Nasal Cannula in Morbidly Obese Patients Undergoing General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Measurement of safe apnea time
研究概览
简要总结
Before going off to sleep patients are given oxygen to saturate blood with oxygen to extend time before a decrease in the level of oxygen in the blood occurs. During this period, obese patients have a faster decrease in the level of oxygen in their blood. This study uses a device called "high-flow nasal cannula" (HFNC), which delivers humidified high-flow oxygen through 2 small plastic tubes placed just inside nostrils. In the intensive care unit settings this device has been used extensively and has become a standard practice. Purpose of this study is to determine whether these high-flow nasal cannula increase the time safely when going to sleep during elective surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than18 years old
- •ASA status I-III
- •Elective surgery performed under general anesthesia requiring endotracheal intubation
- •BMI more than 40 kg/m2
排除标准
- •Chronic respiratory disease
- •SpO2 <98% after supplementing oxygen
- •Previous or anticipated difficult intubation
- •Uncontrolled hypertension
- •Ischemic heart disease
- •Congestive heart failure
- •Increased intracranial pressure
- •Uncontrolled GERD
- •Known allergy or contraindication to anesthesia drugs
- •Nasal blockade contraindicating the use of HFNC
研究组 & 干预措施
HFNC (High Flow Nasal Cannulae)
High Flow Nasal Cannulae providing humidified, high-flow oxygen during induction of anesthesia
干预措施: HFNC (Device)
CON (control)
Standard flow oxygen during induction of anesthesia
干预措施: CON (control) (Device)
结局指标
主要结局
Measurement of safe apnea time
时间窗: Maximum up to 6 minutes
Safe apnea time, defined by time to desaturation (SpO2 \> 95%) or apnea maximum up to 6 minutes
次要结局
- Highest EtCO2(Every minute up to 5 minutes on commencing ventilation)
- Time to regain baseline SpO2(Up to 5 minutes after intubation)
- Lowest SpO2(Every minute up to 5 minutes after intubation)
研究者
David Wong
Professor Anesthesia (MD)
University Health Network, Toronto