Incidence of Hypotension Based on the Discontinuation Order of Vasopressors in the Management of Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Incidence of hypotension
研究概览
简要总结
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.
详细描述
There are little data regarding the discontinuation of vasopressors in patients with septic shock. Therefore, the investigators intend to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients 20 years of age or older
- •patients of receiving concomitant therapy with norepinephrine and vasopressin for teh management of septic shock
- •patients began to reduce the vasopressor
排除标准
- •patients who expired or had care withdrawn while receiving norepinephrine and vasopressin
- •patients being transferred into the ICU from an outside facility or the operating room
- •patients who are suspected to have vasopressin deficiency (eg. HPA axis dysfunction, empty sella)
- •acute myocardial infarction or Congestive heart failure (NYHA functional classification III or IV)
- •acute mesenteric ischemia
- •patients who were received other vasopressor except for norepinephrine or vasopressin
研究组 & 干预措施
Vasopressin
Vasopressin will be reduced first (0.01 U/hour)
干预措施: Vasopressin (Drug)
Norepinephrine
Norepinephrine: Norepinephrine will be reduced first (0.1 microgram/kg/hour)
干预措施: Norepinephrine (Drug)
结局指标
主要结局
Incidence of hypotension
时间窗: One hour after dose reduction of vasopressors
Hypotension is defined as mean arterial pressure is less than 65mmHg
次要结局
- Time of hypotension(One hour after dose reduction of vasopressors)
- Vasopressor free day(28 days after dose reduction of vasopressors)
- 28-day mortality(28 days)
- ICU mortality(3 months)
- In-hospital mortality(3 months)
研究者
Kyeongman Jeon
Assistant professor
Samsung Medical Center