Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP

Not Applicable

• Conditions: ECMO; COVID-19
• Interventions: Device: Low flow ECMO driving by CVVH machine

• Registration Number: NCT04340414
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-20
• Study First Submitted: 2020-03-03
• Study First Submitted QC: 2020-04-08
• Study First Posted: 2020-04-09
• Status Verified: 2020-06
• Last Update Submitted: 2020-06-13
• Last Update Posted: 2020-06-16
• Primary Completion: 2020-08-15
• Study Completion: 2020-10-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• 1. NCP with severe acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)<150 and PEEP >10cmH2O
• 2. Driving pressure> 20cmH2O
• 3. RR>30bpm
• 4.PaCO2>55cmH2O and/or PH>7.3

Exclusion Criteria

• 1. poor venous vascular condition and unavaible for central venous catheter placement

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
NCP patient with severe ARDS and/or high ventilator supported	Low flow ECMO driving by CVVH machine	The NCP patient with severe ARDS and/or high ventilator supported condition was eligibilitable for enrollment

Primary Outcome Measures

Name	Time	Method
PaCO2	Day 1	PaCO2 from blood gas analysis
Tidal volume	Day 1	Tidal volume monitor by ventilator
Driving Pressure	Day 1	Driving Pressure monitor by ventilator

Trial Locations

Locations (1)

Yun Long; 🇨🇳 Beijing, Beijing, China