NCT04340414UnknownNot Applicable
Safety and Effectiveness Study of Low Flow Extracorporeal Membrane Oxygenation（CO2 Removal） Driving by Continuous Hemofiltration Machine the Severe New Corovirus Pneumonia (NCP)
Peking Union Medical College Hospital1 site in 1 country10 target enrollmentStarted: February 20, 2020Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- PaCO2
Study Overview
Brief Summary
assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 14 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •NCP with severe acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)<150 and PEEP >10cmH2O
- •Driving pressure> 20cmH2O
- •4.PaCO2>55cmH2O and/or PH>7.3
Exclusion Criteria
- •poor venous vascular condition and unavaible for central venous catheter placement
Outcomes
Primary Outcomes
PaCO2
Time Frame: Day 1
PaCO2 from blood gas analysis
Tidal volume
Time Frame: Day 1
Tidal volume monitor by ventilator
Driving Pressure
Time Frame: Day 1
Driving Pressure monitor by ventilator
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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