Blood Flow Restriction Training in Multiple Sclerosis

Not Applicable

Recruiting

• Conditions: MS
• Interventions: Other: strengthening ex; Other: strengthening ex with BFR training

• Registration Number: NCT06143930
• Lead Sponsor: Cairo University

Brief Summary

Traditional physical therapy resisted training for people with MS have been shown to be beneficial; however, their usefulness has been limited by fatigue. The effect of blood flow restriction on strength and other measures of physical function was demonstrated in healthy populations and those with chronic disease. This study may add missing information to the existing literature and suggests directions for research on the effectiveness of BFR training on individuals with relapsing and remitting MS.

Detailed Description

Multiple sclerosis patients are characterized by impaired functional capacity which is related to reduce muscle strength affecting predominantly the lower extremity.

Resistance training (RT) has proven to be one of the interventions in MS patients showing a consistent and positive effect on muscle strength and on parameters directly related to lower extremity physical function (eg, walking performance and stair negotiation).

Training with blood flow restriction (BFR), is an increasingly common clinical intervention among physical therapists over the past decade and consistent with the evidence. It has been investigated in people with neurological disorders including stroke and incomplete Spinal Cord Injuries. Research is limited on the use of BFR for individuals with MS.

Study Timeline

• Study Start: 2023-07-01
• Study First Submitted: 2023-10-25
• Status Verified: 2023-11
• Study First Submitted QC: 2023-11-16
• Last Update Submitted: 2023-11-16
• Study First Posted: 2023-11-22
• Last Update Posted: 2023-11-22
• Primary Completion: 2024-04
• Study Completion: 2024-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1. Patients were diagnosed with MS by a neurologist according to McDonald's criteria 2010
2. Expanded Disability Status Scale (EDSS) scores ranging from 2.5 to 5.5 .
3. Patient able to walk 100 meters or more.
4. No change within MS specific medication three months from the study.
5. Last Ms Attack from more than two months.

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Exclusion Criteria

1. Multiple sclerosis patients with other neurological or orthopedic problems.

2. Multiple sclerosis patients with systemic problems (cardiovascular or pulmonary diseases...).

3. Patients with cognitive impairment.

4. Pregnant female patients.

5. Patients in acute relapse stage.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The control group (A) will receive therapeutic strengthening training program for lower extremities.	strengthening ex	low intensity strengthening exercise program
The study group (B) will receive strengthening training with blood flow restriction	strengthening ex with BFR training	the same selected low intensity resisted exercise program as group (A) with blood flow restriction

Primary Outcome Measures

Name	Time	Method
muscle strength	one week after the end of treatment	measure maximal torque production at a specified velocity of limb movement. measure torque of hip flexors , extensors , knee flexors and extensors

Secondary Outcome Measures

Name	Time	Method
gait performance by Two-dimensional (2D) Motion Analysis system	one week after the end of treatment	kinematic analysis of gait (step length , stride length)

Trial Locations

Locations (1)

Faculty of physical therapy; 🇪🇬 Giza, Egypt