Effects of HIIT on Metabolic Syndrome

Not Applicable

• Conditions: Blood Pressure; Obesity; Dyslipidemias; Metabolic Syndrome; Sedentary Behavior
• Interventions: Behavioral: Low Volume-High Intensity Interval Training; Behavioral: Moderate Intensity Continuous Training

• Registration Number: NCT04133129
• Lead Sponsor: Coventry University

Brief Summary

The project aims to find out the differences between two different types of structured training interventions have on the lipid profile of persons with diagnosed dyslipidemia. Each training intervention will last for 12 weeks. Subjects participating in the project will undergo a series of tests before and after the training intervention which will allow us to make conclusions.

Detailed Description

The purpose of this project is to compare the effect that two different types of aerobic training modes have on the lipid profile of subjects with pre-symptoms of metabolic syndrome. One training mode will involve High-Intensity Interval Training and the other will involve medium intensity continuous training. The desired outcomes of this project are to know the effects of both modes of training have on the long-term on the lipid profile in order to help develop a nonpharmacologic alternative to prevent or treat metabolic syndrome and to know how affective and enjoyment responses are affected by the different modes of training. The Project lasts for 16 weeks. Training will take place during weeks 3 and 14 of the project. The project will be described fully to the participants during the 1st week. In addition to this, their rights as participants will be explained in addition to any possible ethical issues that might require clarifying. Once the subjects have agreed to take part in the research they will undergo a series of tests in order to asses their cardiorespiratory fitness and their lipids profile. Before starting the training intervention participants will be randomly assigned to one of the 3 different groups; Control, Medium Intensity Continuous Training and Low Volume High-Intensity Interval Training. Between weeks 3 and 14 subjects will take part in 3 training sessions per week. At week 15 and 16 subjects will undergo the same tests as during week 1 and 2.

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-16
• Study First Submitted QC: 2019-10-18
• Last Update Submitted: 2019-10-18
• Study First Posted: 2019-10-21
• Last Update Posted: 2019-10-21
• Study Start: 2019-11-01
• Primary Completion: 2020-03-02
• Study Completion: 2020-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Fasted Blood Glucose >100 mg/dL
• Total Cholesterol >200 mg/dL
• Blood Pressure >130/90 mmHg
• Do not partake in more than 150 min/week of moderate to vigorous exercise

Exclusion Criteria

• Existing or past medical history of vascular disease, cancer, diabetes, osteoporosis, neurological, kidney, pulmonary, digestive (Coeliac disease), thyroidal disease.
• Musculoskeletal injuries
• Neuromuscular disorders or injuries
• Individuals with a pacemaker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LV-High Intensity Interval Training	Low Volume-High Intensity Interval Training	2 x 4 minutes at 85%-95% of Heart rate max.
Moderate Intensity Continuous Training	Moderate Intensity Continuous Training	1 x 45 minutes at 65%-75% of Heart rate max.

Primary Outcome Measures

Name	Time	Method
Blood Pressure (mmHg)	0 to 12 weeks	Evaluate change in Systolic and Diastolic Blood Pressure
Cardiorespiratory Fitness (ml/kg/min)	0 to 12 weeks	Evaluate change in maximal oxygen uptake (VO2max) via breath by breath analysis performed on a treadmill.
Biochemical: Lipid Profile	0 to 12 weeks	Evaluate change in Very Low-Density Lipoproteins (VLDL), High Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL) in (mg/dl) with Liposcale® test, an advanced lipoprotein test based on 2D Nuclear Magnetic Resonance (NMR).
Changes in Body Composition (kg)	0 to 12 weeks	Evaluate changes in Fat-free mass, fat mass, skeletal muscle mass measured by bio-electrical impedance analysis.

Secondary Outcome Measures

Name	Time	Method
Changes in exercise enjoyment	0 to 12 weeks	The investigators will assess perceived exercise enjoyment at baseline and post intervention using The Physical Activity Enjoyment Scale (PACES). (PACES) is an 18-item measure, scored on a 7-point bipolar scale based on the instruction; "Please rate how you feel at the moment about the physical activity you have been doing:"
Change in Behavioural Regulations in Exercise Questionnaire-2 (BREQ-2) over time	0 to 12 weeks	Behavioural Regulations in Exercise Questionnaire-2 (BREQ-2) is a 19 item self-report scale. It uses a Likert-type scale of 5 points, where 0 = not true for me and 4 = very true for me

Trial Locations

Locations (1)

CDM GO fit Vallehermoso; 🇪🇸 Madrid, Spain