Evaluation of anti-inflammatory effects of colchicine on the blood flow of heart's vessels and heart's muscle in patients who undergo angioplasty in the acute phase of heart attack

Not Applicable

Recruiting

Conditions: Acute myocardial infarction.
ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Registration Number: IRCT20120111008698N23

Lead Sponsor: Deputy of Research and Technology of Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 320

Inclusion Criteria

Patients who are candidates for the Primary PCI
Pain or chest discomfort greater than or equal to 20 minutes, less than or equal to 12 hours, and ST elevation = 1 mm in the adjacent limb leads and precordial leads except for V2, V3, or ST elevation = 2 mm in V2, V3 in men or ST height = 1.5 mm in V2, V3 in women.
Obtain informed consent from all patients before enrollment

Exclusion Criteria

Patients who are only undergoing angiography for diagnostic purposes and do not undergo PCI
Patients who have been treated with Colchicine due to chronic illness
Colchicine intolerance history
Glumerolar filtration Rate less than 30 ml/min and Dialysis patients
Malignancy and infection
Oral steroids or NSAIDs ( Except for aspirin) within 72 hours prior to PCI
Use of CYP 3A4 / P-glycoprotein inhibitor drugs (Ritonavir / Ketoconazole / Clarithromycin / Cyclosporine / Diltiazem / Vrapaemia)
Patients who suffered cardiac arrest, cardiogenic shock (systolic pressure less than 90), VF, or under CPR in emergency setting
Start angina more than 12 hours

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary blood flow and myocardial perfusion. Timepoint: during angiography. Method of measurement: TIMI flow criteria and observations during the angiography.

Secondary Outcome Measures

Name	Time	Method
Hs-CRP. Timepoint: baseline and 48 hours after PCI. Method of measurement: blood sample.;TNT. Timepoint: baseline and 6 hours and 24 hours and 48 hours after PCI. Method of measurement: blood sample.;P-selectin. Timepoint: baseline and 24 hours after PCI. Method of measurement: blood sample.;30 day MACE. Timepoint: one month after PCI. Method of measurement: follow-up visit or phone call.