The Search for Viral and Bacterial Etiology of Varicocele
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Level of presence od viral or bacterial infection, level of expression of SHH and VEGF in varicose vein wall. .
研究概览
简要总结
This study is to answer the question is there any relationship between viral ( HSV 1 , HSV 2 , HPV 6/11, CMV, HHV 6 , HHV 8, BKV) or bacterial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum) infection and occurrence of varicocele in men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •in experimental arm - varicocele grade II or III and infertility and/or pain
排除标准
- •in control arm: presence of varicocele in ultrasound before surgery
研究组 & 干预措施
microsurgery urology
20 patients with varicocele (grade II or III) undergoing subinguinal microsurgery varicocelectomy due to infertility and/or pain in the scrotum.
干预措施: subinguinal microscopic varicocelectomy (Procedure)
open general surgery
20 patients (without varicocele) undergoing open hernia repair.
干预措施: open hernia repair (Procedure)
结局指标
主要结局
Level of presence od viral or bacterial infection, level of expression of SHH and VEGF in varicose vein wall. .
时间窗: one year after finishing recruitment
Qualitative and quantitive analysis (presence and concentration - µl or U/µl in two different laboratory tests.) to detect genetic material (DNA, mRNA) of bacteria/viruses will be performed. The outcomes from both gropus will be compared.
次要结局
未报告次要终点