Oncolytic Virus (OH2) Adjuvant Therapy After Transurethral Resection of Bladder Tumor in Non-Muscle-Invasive Bladder Cancer Who Have Failed First-line Prophylactic Intravesical Instillation Therapy: a Phase Ⅰb/Ⅱ Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- AEs
研究概览
简要总结
This phase Ⅰb/Ⅱ study evaluates the safety and efficacy of OH2 for adjuvant therapy in non-muscle-invasive bladder cancer after first-line prophylactic intravesical instillation therapy.
OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. Meanwhile, the delivery of the gene encoding human granulocyte macrophage colony-stimulating factor (GM-CSF) may induce a more potent antitumor immune response.
详细描述
This is a phase Ⅰb/Ⅱ study evaluating the safety and efficacy of OH2 in non-muscle-invasive bladder cancer.
BH-OH2-016 is a single-arm,multicenter clinical trial. After screening, The treatment period includes induction treatment period and maintenance treatment period. In the induction treatment period, OH2 will be delivered once two weeks. In the maintenance treatment period, OH2 will be delivered once a month. In this trial, two doses (1x10e6, 1x10e7 CCID50/mL) of OH2 will be delivered intravesical instillation，and the 1x10e6 CCID50/mL dose group should be delivered before the 1x10e7 CCID50/mL dose group.
Adverse events (AEs) are graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) (version 5.0).Urine cytology/Cystoscopy/ultrasonography of urinary system will be used for disease recurrence examination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 ~ 80 years old (including boundary value), male or female.
- •Failed in first-line preventive bladder perfusion therapy, and retained the bladder (or other reasons are not suitable for radical total cystectomy).
- •Ta, T1 or Tis with high grade (HG) of non-muscle-invasive bladder cancer.
- •Negative histology and pathology of bladder mucosa biopsy and negative postoperative urine cytology during TURBT.
- •No tumor was found in upper urinary tract examination; No systemic chemotherapy or radiation therapy for bladder cancer has been done at any time before.
- •The estimated survival time is more than 1 year.
- •Laboratory inspection:
- •WBC≥3.5 × 10^9／L，ANC≥1.5 × 10^9／L，PLT≥80 × 10^9／L，Hb≥90g/L；
- •Blood bun and serum creatinine were within 1.5 times of the upper limit of normal value;
- •TBIL ≤ 1.5 times the upper limit of normal value;
- •ALT and AST ≤ 2.5 times the upper limit of normal value;
- •The coagulation function is normal (PT and APTT are within 1.5 times of the upper limit of normal value).
- •Received effective contraception during and within 3 months after treatment.
- •At least 3 months after the end of herpes infection.
- •Voluntary signing of informed consent, expected patient compliance
排除标准
- •muscle invasive bladder cancer or bladder cancer with clinical metastasis.
- •Complications occurred after TURBT, or perfusion therapy could not be performed.
- •Allergic to GM-CSF products or have a history of allergic reaction to the main and auxiliary materials of any dosage form in the study drug.
- •Suffering from serious medical diseases, including severe heart disease, cerebrovascular disease, uncontrolled diabetes, uncontrolled hypertension, severe infection, active gastrointestinal ulcer.
- •Chemotherapy or radiotherapy is expected to be used during the study.
- •Active infection or fever of unknown cause > 38.5 ℃ during screening and before the first administration. Ongoing urinary system infection, especially bladder infection (if the infection can be controlled by antibiotics, except that it can return to normal after 7 days of antibiotic withdrawal).
- •Congenital or acquired immune deficiency (such as HIV infection) , Hepatitis B infection of HBV-DNA or more than 10 /mL, HCV antibody and HCV RNA positive in hepatitis C infection.
- •Pregnant or lactating.
- •Other experimental drugs or antiviral therapy were used or are being used within 4 weeks before treatment.
- •Participated in immunosuppressive therapy in recent 3 months, including cyclosporine, antithymocyte globulin or tacrolimus.
- •Participated in cancer vaccine treatment trials in recent 12 months (such as dendritic cell therapy and heat shock vaccine).
- •History of psychotropic substance abuse, alcoholism or drug abuse.
- •Other malignant tumors within 5 years before enrollment, except effectively resected cervical carcinoma in situ, low-risk gastrointestinal stromal tumor, skin basal cell carcinoma, skin squamous cell carcinoma, thyroid papillary carcinoma and breast ductal carcinoma in situ.
- •Active autoimmune diseases or history of autoimmune diseases and may relapse, except:
- •Type I diabetes mellitus;
- •Hypothyroidism (if only controlled by hormone replacement therapy);
- •Controlled celiac disease;
- •Skin diseases that do not require systemic treatment (such as vitiligo, psoriasis, hair loss);
- •Any other disease that will not recur without external triggers.
- •Using corticosteroids within 14 days before the administration of the study drug due to treatment, or suffering from any disease requiring systemic treatment with other immunosuppressants, except:
- •Local, ophthalmic, intra-articular, intranasal or inhaled corticosteroids with minimal systemic absorption;
- •Prophylactic short-term use of corticosteroids (e.g., allergy to contrast agents) or for the treatment of non autoimmune diseases (e.g., delayed hypersensitivity caused by contact allergens).
- •Not suitable to participate study judged by investigators for any reason.
结局指标
主要结局
AEs
时间窗: 1 years
All events with a Grade 3 or above toxicity (defined by the CTCAE v5.0) will be tabulated by event and by relationship to OH2.
Relapse Free Survival Rate at 6 months
时间窗: 6 months
The assessment result is the number and proportion of subjects with relapse free survival at 6 months.
Rate of disease progression
时间窗: 1 years
Time after OH2 administration to clinical and radiographic disease progression will be evaluated.
Relapse Free Survival Rate at 12 months
时间窗: 12 months
The assessment result is the number and proportion of subjects with relapse free survival at 12 months.
次要结局
未报告次要终点