Impact of Dapagliflozin on DIAstolic Dysfunction in Type 2 Diabetic Patients: The IDDIA Study
Overview
- Phase
- Phase 4
- Intervention
- Dapagliflozin 10mg
- Conditions
- Type 2 Diabetes Mellitus
- Sponsor
- Yonsei University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- subclinical diastolic dysfunction assessed by supine bicycle diastolic stress echocardiography
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study aims to assess the impact of 24-week treatment of dapagliflozin in type 2 DM(diabetes mellitus) patients on diastolic dysfunction. Primary endpoint is assessing the impact of 24-week treatment of dapagliflozin in type 2 DM patients on subclinical diastolic dysfunction assessed by supine bicycle diastolic stress echocardiography. Secondary endpoint is assessing the impact of 24-week treatment of dapagliflozin in type 2 DM patients on functional capacity, he impact of 24-week treatment of dapagliflozin in type 2 DM patients at resting diastolic function. This is single-center, randomized, double-blind, placebo-controlled, parallel-arm intervention study.
This study is planned to evaluate the impact of dapagliflozin on diastolic dysfunction assessed. The dose of dapagliflozin will be 10 mg as approved.
For assessment of diastolic dysfunction, supine bicycle stress exercise echocardiography was performed, and changes in diastolic functional reserve, VO2max, exercise time, and maximal exercise capacity were assessed before and after treatment. This study will be randomized, double blind, placebo controlled, to minimize the risk of bias.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Female and male aged 19\~75 years
- •Type 2 DM and had not reached adequate glycemic control with a stable dose of metformin, sulfonylurea, or both drugs before screening
- •HbA1c 7.0% \~ 10% at screening (Patients who take metformin only: HbA1C 6.5-10%)
- •Patients with ≥ grade 1 diastolic function (relaxation abnormality) at resting echocardiography
- •Patients provided with the written, informed consent to participate in this study
Exclusion Criteria
- •Type 1 DM (Fasting c-peptide ≤ 0.78ng/dL(or 0.26 nM/L)), secondary diabetes, gestational diabetes
- •History of diabetic ketoacidosis, hyperglycemic hyperosmolar status
- •Estimated glomerular filtration rate \< 60 mL/min/1.73m2
- •History of chronic cystitis or recurrent urinary tract infection
- •Currently on loop diuretics
- •Currently on medication known to affect glucose metabolism (e.g. corticosteroids, immunosuppressants)
- •Abnormal liver function (AST/ALT \> x3 upper normal limit)
- •On weight loss program or taking weight loss medication
- •LV ejection fraction \< 50% at resting echocardiography
- •Uncontrolled hypertension (systolic blood pressure \>200mmHg and/or diastolic blood pressure \>110mmHg)
Arms & Interventions
Dapagliflozin
Dapagliflozin 10mg/day
Intervention: Dapagliflozin 10mg
Placebo
Intervention: Placebo 10mg
Outcomes
Primary Outcomes
subclinical diastolic dysfunction assessed by supine bicycle diastolic stress echocardiography
Time Frame: 24-week
Secondary Outcomes
- the impact of dapagliflozin on patients' functional capacity(24-week)
- the impact of dapagliflozin on resting diastolic function(24-week)