Double-Blind Treatment of Mild Cognitive Impairment (MCI) With Transdermal Nicotine or Transdermal Placebo
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 75
- 试验地点
- 3
- 主要终点
- Safety of transdermal nicotine patch
研究概览
简要总结
The purpose of this 12-month study is to determine whether nicotine, administered in the form of nicotine patches, can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as "mild cognitive impairment" or MCI).
详细描述
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as "mild cognitive impairment" or MCI). The study will last approximately 12 months and will be conducted at 3 clinical sites in the United States.
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our mood. In MCI (and Alzheimer's disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer's disease. Nicotine imitates many of the actions of acetylcholine. By administering nicotine over a longer period of time to patients with MCI, this study could lead to a better understanding of whether nicotine can act to improve memory loss symptoms over the longer term and whether it can help delay the progression of memory loss symptoms. The amount of nicotine in each patch used in this study is the same level found in patches that are used in people who are trying to quit smoking.
This study will include up to twelve visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Memory complaints and memory difficulties which are verified by an informant.
- •Abnormal memory function documented by scoring below the education adjusted cutoff on the Logical Memory II subscale (Delayed Paragraph Recall) from the Wechsler Memory Scale - Revised (the maximum score is 25):
- •less than or equal to 8 for 16 or more years of education,
- •less than or equal to 4 for 8 - 15 years of education,
- •less than or equal to 2 for 0 - 7 years of education.
- •Mini-Mental Status Exam score between 24 and 30 (inclusive).
- •Clinical Dementia Rating of 0.5 with a memory box score of 0.5 or 1.
- •General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer's disease cannot be made by the site physician at the time of the screening visit.
- •No significant cerebrovascular disease: Modified Hachinski score of less than or equal to
- •Stable medications for at least 1 month prior to screening.
- •Hamilton Depression rating scale score of less than or equal to 12 on the 17-item scale.
- •Informant is available who has frequent contact with the participant (e.g. an average of 10 hours per week or more).
- •Adequate visual and auditory acuity to allow neuropsychological testing.
- •Good general health with no additional diseases expected to interfere with the study.
- •Any conditions that subject may have must be stable for 3 months prior to screening.
- •Participant is not pregnant, lactating, or of childbearing potential (i.e. women must be two years post-menopausal or surgically sterile).
- •Participants will be taking no drugs with pro- or anti-cholinergic properties.
排除标准
- •Any significant neurologic disease such as Alzheimer's disease, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic deficits or known structural brain abnormalities.
- •Major depression or another major psychiatric disorder as described in DSM-IV within the past 2 years.
- •History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
- •Any significant, unstable medical condition.
- •Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening.
- •Any tobacco use within the past year.
- •Exceptions to these specific Inclusion and Exclusion Criteria (e.g., WMS-R cutoffs) may be made on a case by case basis by the Principal Investigator.
研究组 & 干预措施
Placebo Group
Placebo for first six months of study; moved to open-label active nicotine for second six months
干预措施: Placebo transdermal patch (Drug)
Active Nicotine Group
Blinded active nicotine for first six months of study; open-label active nicotine for second six months
干预措施: Transdermal nicotine patch (Drug)
结局指标
主要结局
Safety of transdermal nicotine patch
时间窗: 13 months
次要结局
- Change in cognitive performance(13 months)
- Change in global functioning(13 months)