A comparative study on efficacy and safety of oral zinc vs oral doxycycline vs combined oral zinc and doxycycline in treatment of mild to moderate facial acne vulgaris with topical benzoyl peroxide as common standard therapy - a randomised controlled trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 63
- 试验地点
- 1
研究概览
简要总结
It is a randomized, parallel group, active controlled, interventional clinical trial
To compare the efficacy and safety of oral zinc, oral doxycycline, and their combination, each given along with topical benzoyl peroxide 2.5 percent gel as standard therapy, in patients with mild to moderate facial acne vulgaris.
Eligible participants will be randomized into three groups to receive either oral zinc acetate 50 mg elemental zinc once daily , oral doxycycline 100 mg once daily, or oral zinc 50 mg plus oral doxycycline 100 mg once daily, for a period of eight weeks.
Objectives are
To assess the efficacy of oral zinc in treatment of mild to moderate acne vulagris
To assess the efficacy of oral doxycycline in treatment of mild to moderate acne vulagris
To investigate whether a combination therapy of zinc and doxycycline provide superior clinical outcome compared to monotherapy.
To study the side effects profiles among three groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- All
入选标准
- •Age group 18-35 years Male or Female patients Clinically diagnosed with acne vulgaris of grades I , II , III.
- •More than 10 lesion count Agreed to sign the consent to be included in the study.
排除标准
- •systemic antibiotics in last 4 weeks , systemic isotretinoin in last 6 months known allergy to study medications Additional facial dermatoses (atopic and seborrheic dermatitis) severe nodulocystic acne Female Patients who are pregnant and lactating.
研究者
Hrishita Vijay Punjabi
MGM Medical College and Hospital Aurangabad