Evaluation of the effect of memantine on diabetic neuralgia(diabetic nouropathy)(DN)

Phase 2

Recruiting

• Conditions: E11.42; diabetic nouropathy.; Type 2 diabetes mellitus with diabetic polyneuropathy

• Registration Number: IRCT20180404039187N5
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients with diabetic neuropathy (PDN) aged between 18 and 75 years who have been diagnosed with PDN due to physical examinations. And patients treated with gababirzin (gabapentin and pregabalin)

Exclusion Criteria

Pregnancy- Lactation- Cardiovascular disease- The presence of other neuropathies, such as neuropathy caused by herpes and trigeminal neuralgia, and ...- Sensitization to memantine or other formulation components- Uncontrolled hypertention- Epilepcy- Liver failure- Renal insufficiency with creatinine clearance less than 30 ml / min

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fasting blood sugar level. Timepoint: At the beginning and 3 months after intervention. Method of measurement: Enzymatic method with Pars Azmoon kit.;Glycosylated hemoglobin (three months sugar)(A1C). Timepoint: At the beginning and 3 months after intervention. Method of measurement: Immunoturbidimetry? autoanalyzers assay.;Heat and cold test. Timepoint: At the beginning and 3 months later. Method of measurement: Using a thermophile tool (Diagnostic Tool for Neuropathy).;Diapazon test. Timepoint: At the beginning and 3 months later. Method of measurement: Using Diapazone (Diagnostic Tool for Neuropathy).;Monofilament. Timepoint: At the beginning and 3 months later. Method of measurement: Using a monofilament device (a diagnostic tool for neuropathy).;Pain and numbness on the soles of the feet and hands. Timepoint: At the beginning and 3 months later. Method of measurement: DN4 questionnaire.