Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults

Not Applicable

Completed

• Conditions: Mobility Limitation
• Interventions: Dietary Supplement: Maltodextrin placebo; Dietary Supplement: Whey protein

• Registration Number: NCT00635739
• Lead Sponsor: Tufts University

Brief Summary

This research study is looking at the effects of a whey protein nutritional supplement on changes in muscle mass, strength and physical function in response to a 6 month program of strength training exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-03-07
• Study First Submitted QC: 2008-03-13
• Study First Posted: 2008-03-14
• Study Start: 2008-04
• Primary Completion: 2011-05
• Study Completion: 2011-05
• Results First Submitted: 2017-05-26
• Status Verified: 2018-12
• Results First Submitted QC: 2018-12-04
• Last Update Submitted: 2018-12-04
• Results First Posted: 2019-03-18
• Last Update Posted: 2019-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Male and Females 70-85 yrs
• Community dwelling
• Short Physical Performance Battery score < 10
• BMI = 21-32.5

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Exclusion Criteria

• Acute or terminal illness
• Mini Mental State Exam < 23
• Myocardial infarction in previous 6 months, symptomatic coronary artery disease, or congestive heart failure
• Upper or lower extremity fracture in previous 6 months
• Uncontrolled hypertension (>150/90 mm Hg).
• Neuromuscular diseases and drugs which affect neuromuscular function.
• Hormone replacement therapy
• eGFR <30 mL/min/1.73m2
• Types I and II Diabetes Mellitus
• Dietary protein intake < 0.8 g.kg-1.day-1
• Disorders of nutrient absorption
• Milk, or whey allergy
• Sulfa drugs and allergy to PABA-containing sunscreens

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A, 2	Maltodextrin placebo	-
A, 1	Whey protein	-

Primary Outcome Measures

Name	Time	Method
1 Repetition Maximum Muscle Strength 1-RM (N) Double Leg Press	Baseline and follow up (6 months)	The maximum muscle strength of the leg extensor muscles as measured by pneumatic strength training equipment.

Secondary Outcome Measures

Name	Time	Method
Lean Mass	Baseline and follow up (6 months)	Whole body lean mass (kg) as measured by dual energy x-ray absorptiometry.

Trial Locations

Locations (1)

Jean Mayer USDA Human Nutrition Research Center on Aging; 🇺🇸 Boston, Massachusetts, United States