Investigation of the prophylactic effects of lisinopril on chronic migraine
Phase 3
- Conditions
- migraine.
- Registration Number
- IRCT201701089157N5
- Lead Sponsor
- Iranian Center of Neurological Research, Tehran University of Medical Sciences,
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 112
Inclusion Criteria
Patients will be included in the study due to the following inclusion Criteria:
having = 15 headache days per month for at least 3 months,
history of migraine for at least 1 year,
age 18-45 years,
systolic blood pressure between 110-140 mmHg
Taking a large amount of abortive drugs.
The exclusion criteria were as follows:
having psychiatric illness,
having major neurological disorders and / or other chronic or systemic diseases,
being pregnant or have a planned pregnancy,
breastfeeding,
taking prophylactic medications in the last 4 weeks,
suffering from impaired liver function or kidney disorders,
allergies to ACE inhibitors,
history of angionearotic edema
suffering from secondary headaches.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Migraine headache severity. Timepoint: first month, second month, third month. Method of measurement: Visual Analog Scale (VAS).;Migraine headache duration. Timepoint: first month, second month, third month. Method of measurement: Migraine headache diary.;Migraine headache frequency. Timepoint: first month, second month, third month. Method of measurement: Migraine headache diary.
- Secondary Outcome Measures
Name Time Method Remission from Chronic Migraine to Episodic Migraine. Timepoint: first week, second month. Method of measurement: physical examination, headache diary.