The Effect of Hyaluronic Acid Gel on Relieving Post-Implantation Pain

Not Applicable

Completed

• Conditions: Implant Complication
• Interventions: Biological: Hyaluronic Acid

• Registration Number: NCT05776290
• Lead Sponsor: Damascus University

Brief Summary

Few previous studies have employed HA in the implant socket; instead, the majority have applied it topically to the area around dental implants after they have been placed. The application was done after suturing in these investigations. Therefore, the goal of the current study was to inject HA into the implant socket and onto the alveolar bone prior to implant insertion and suturing in order to preserve the HA for an extended period of time.

This study aims to use a visual analog scale (VAS) on the first, third, and tenth days following the surgical intervention to assess the efficacy of employing HA in dental implants in terms of pain reduction that may accompany dental implant surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-15
• Primary Completion: 2022-03-15
• Study Completion: 2022-05-15
• Study First Submitted: 2023-03-08
• Study First Submitted QC: 2023-03-08
• Study First Posted: 2023-03-20
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-05
• Last Update Posted: 2023-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• bilateral tooth loss with a sufficient amount of bone volume
• no general problems
• good oral health
• age between 20 and 60 years

Exclusion Criteria

• the use of immunosuppressive drugs and corticosteroids for long periods
• the existence of serious systemic disorders
• contraindications for local anesthesia or oral surgery
• pregnant women and nursing mothers
• patients receiving chemotherapy or radiation
• alcoholics and heavy smokers.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyaluronic acid injection	Hyaluronic Acid	The hyaluronic acid will be injected into the implant socket before implantation.

Primary Outcome Measures

Name	Time	Method
Change in the Perception of pain	First assessment: at 24 hours following the surgical procedure. Second assessment: at 72 hours following the surgical intervention. Third assessment will be made on the tenth day following the surgical intervention	This will be measured using a numeric rating scale. Patients will be asked to indicate the level of pain they perceive on a scale from 1 to 10. The intensity of pain is going to be classified according to the following categories: 0 = no pain, 1-3 = mild pain, 3-6 = moderate pain, and 6-10 = severe pain.

Trial Locations

Locations (1)

Department of Oral Medicine, Faculty of Dentistry, University of Damascus; 🇸🇾 Damascus, Syrian Arab Republic