NCT00915447WithdrawnNot Applicable
Diesel Exhaust Particles and Leukotriene Production
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Locations
- 1
Study Overview
Brief Summary
The purpose of this study is to measure the effects of allergens and/or diesel exhaust particles in the nose to learn more about allergic responses in individuals with cat allergic rhinitis.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 18 to 65 years old.
- •Positive prick (epicutaneous) skin test to standardized cat with a wheal equal to or greater than 3 mm and with a surrounding flare.
- •Ability to give informed consent.
Exclusion Criteria
- •Pregnancy or breast-feeding. (Pregnancy and the period during breast feeding can affect nasal congestion and be a confounder in this regard.)
- •Systemic corticosteroid use within the previous three months or anytime during the challenge protocol.
- •Topical nasal corticosteroid use within the past month or anytime during the challenge protocol.
- •Systemic antihistamines or decongestant use within past two weeks or anytime during the trial.
- •Chronic sinusitis or chronic non-allergic rhinitis.
- •Use of reserpine.
- •Cigarette smoking within the past year or during the challenge protocol
- •Use of topical nasal antihistamines, chromoglycolates (chromolyn, Cromlon®), decongestants or non-steroidal anti-inflammatory agents (NSIADS) within the preceding week or anytime during the challenge protocol.
- •Present or treatment within the past 10 years with allergy immunotherapy (injections).
- •Present or past treatment with anti-IgE therapy.
- •Any unusual exposure to air pollutants (e.g., working as a diesel mechanic) that, in the opinion of the investigators, might compromise the individual's ability to participate in the study.
- •Living arrangement where the subject has a cat dwelling within the subject's habitation.
- •Any serious heart, lung, neurological or kidney disease that in the opinion of the investigators would impair the individual's ability to participate in the study.
- •Use of asthma-required medications.
Investigators
Study Sites (1)
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