NCT00915447撤回不适用
Diesel Exhaust Particles and Leukotriene Production
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to measure the effects of allergens and/or diesel exhaust particles in the nose to learn more about allergic responses in individuals with cat allergic rhinitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 65 years old.
- •Positive prick (epicutaneous) skin test to standardized cat with a wheal equal to or greater than 3 mm and with a surrounding flare.
- •Ability to give informed consent.
排除标准
- •Pregnancy or breast-feeding. (Pregnancy and the period during breast feeding can affect nasal congestion and be a confounder in this regard.)
- •Systemic corticosteroid use within the previous three months or anytime during the challenge protocol.
- •Topical nasal corticosteroid use within the past month or anytime during the challenge protocol.
- •Systemic antihistamines or decongestant use within past two weeks or anytime during the trial.
- •Chronic sinusitis or chronic non-allergic rhinitis.
- •Use of reserpine.
- •Cigarette smoking within the past year or during the challenge protocol
- •Use of topical nasal antihistamines, chromoglycolates (chromolyn, Cromlon®), decongestants or non-steroidal anti-inflammatory agents (NSIADS) within the preceding week or anytime during the challenge protocol.
- •Present or treatment within the past 10 years with allergy immunotherapy (injections).
- •Present or past treatment with anti-IgE therapy.
- •Any unusual exposure to air pollutants (e.g., working as a diesel mechanic) that, in the opinion of the investigators, might compromise the individual's ability to participate in the study.
- •Living arrangement where the subject has a cat dwelling within the subject's habitation.
- •Any serious heart, lung, neurological or kidney disease that in the opinion of the investigators would impair the individual's ability to participate in the study.
- •Use of asthma-required medications.
研究者
研究点 (1)
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