Passive Heating as an Accessible and Tolerable Strategy to Improve the Inflammatory Profile and Cardiometabolic Health in People With Spinal Cord Injury
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Interleukin-6
Study Overview
Brief Summary
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors that contribute to both heart disease and diabetes. While exercise can help reduce these risk factors, paralysis and impaired accessibility often precludes exercise in persons with SCI. New research in able-bodied persons demonstrates passive heating decreases inflammation and improves vascular function. Similar studies in persons with SCI suggest they may also have the same health benefits however these studies only investigated the impact of short term (one episode) passive heating (as opposed to repeated bouts). Repeated bouts of heat exposure will likely be required to impact chronic inflammation, but this has never been tested in persons with SCI. This study will test the impact of repeated bouts (3x/week) of passive heat stress over a longer term (8 weeks) on inflammation, metabolism and vascular function.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Stable SCI over 1 year of duration
Exclusion Criteria
- •Persons who smoke cigarettes
- •Daily administration of anti-inflammatory medications
- •Daily administration of vasoactive medications
- •Pressure ulcer stage 3 or 4
- •History of heat related illness
Arms & Interventions
Control
Passive heat stress x1 visit then no intervention for 8 weeks. Participants continue regular exercise habits as usual.
Intervention: Control (Other)
Passive heat stress
After arm 1, passive heat stress 3x/week x8 weeks.
Intervention: passive heat stress (Other)
Outcomes
Primary Outcomes
Interleukin-6
Time Frame: change from 0 weeks to 8 weeks to 16 weeks
Plasma concentration, which was determined using enzyme-linked immunosorbent assays.
Secondary Outcomes
- Maximal Cutaneous Vascular Conductance(change from 0 weeks to 8 weeks to 16 weeks)
- Glucose Tolerance(change from 0 to 8 to 16 weeks)
- TNF-alpha(change from 0 to 8 to 16 weeks)
- Interleukin-1ra(change from 0 to 8 to 16 weeks)