Testing TMS Enhancement of Visual Plasticity in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- fMRI Blood Oxygenation Level Dependent (BOLD) Response of Visual Plasticity
研究概览
简要总结
The major goal is to determine if Transcranial magnetic stimulation (TMS) enhances visual plasticity in schizophrenia. TMS sessions (sham/placebo and real TMS) will be conducted before two MRI scans with two weeks in-between to assess whether TMS stimulation to the visual cortex will enhance visual plasticity in patients with schizophrenia-spectrum disorders. This project may provide a better understanding of the underlying neurobiological mechanisms responsible for learning and memory deficits in schizophrenia.
详细描述
Learning and memory impairments are commonly observed in schizophrenia spectrum disorders. Alterations in "long-term potentiation" (LTP), a basic mechanism underlying learning and memory, may explain this impairment. This project will assess fMRI visual plasticity, thought to reflect LTP, in participants with and without schizophrenia spectrum disorders. Previous studies have shown that visual plasticity is impaired in schizophrenia. The major goal is to determine if Transcranial magnetic stimulation (TMS) enhances visual plasticity in schizophrenia. Transcranial magnetic stimulation (TMS) provides a non-invasive means for altering brain electrical neural activity. TMS sessions (sham/placebo and real TMS) will be conducted before two MRI scans with two weeks in-between to assess whether TMS stimulation to the visual cortex will enhance visual plasticity in patients with schizophrenia-spectrum disorders. This project may provide a better understanding of the underlying neurobiological mechanisms responsible for learning and memory deficits in schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age: 18-65,
- •no neurological illness, head trauma, or major medical illness,
- •not pregnant or nursing,
- •no contraindication for TMS or MRI scanning,
- •no current substance abuse/dependence.
- •Healthy controls will have no DSM-5 diagnosis and no first-degree relatives with a psychotic disorder.
- •Inclusion criteria for patients includes:
- •DSM-5 diagnosis of schizophreniform, schizophrenia or schizoaffective and competent to sign an informed consent,
- •not currently taking other medications that affects brain structure (e.g. steroids),
- •less than 12 months antipsychotic exposure and on the same psychotropic medications for 4 weeks prior to study,
- •not be taking clozapine (due to its effects on NMDA receptors and increase of seizure threshold),
- •clinically stable (i.e. no change in psychotic symptoms for at least 4 weeks).
排除标准
- •age outside of 18-65,
- •neurological illness, head trauma, or major medical illness,
- •pregnant or nursing,
- •contraindication for TMS or MRI scanning,
- •current substance abuse/dependence,
- •currently taking medications that affects brain structure (e.g. steroids).
- •Healthy controls with a DSM-5 diagnosis and/or a first-degree relative with a psychotic disorder. Participants with schizophrenia that are not competent to sign an informed consent, have more than 12 months antipsychotic exposure, not on the same psychotropic medications for 4 weeks prior to study, taking clozapine, and not clinically stable (i.e.a change in psychotic symptoms for at least 4 weeks).
研究组 & 干预措施
TMS
rTMS
干预措施: Transcranial Magnetic Stimulation (Device)
Sham TMS
A sham coil will be used. This condition controls for the auditory artifacts induced by rTMS.
干预措施: Transcranial Magnetic Stimulation (Device)
结局指标
主要结局
fMRI Blood Oxygenation Level Dependent (BOLD) Response of Visual Plasticity
时间窗: ~1 hour
fMRI BOLD response in visual cortex, during visual stimulation (0.9 Hz) before and after high frequency visual stimulation (9 Hz).
次要结局
- Magnetic Resonance Spectroscopy (MRS) Assessment of Glutamate(~1 hour)
研究者
Laura Rowland
Associate Professor
University of Maryland, Baltimore