Comparison Between GnRH Agonist Long Protocol And GnRH Antagonist Protocol In Outcome Of The First Cycle ART
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- pregnancy rate
研究概览
简要总结
Literature suggests that GnRH antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. Up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique.
This prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of ART.
The investigators will randomize 160 patients undergoing ART for the first time . Group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with GnRH antagonist and then result of ART compare in two group .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 35 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •first cycle of ART
- •age < 35 years
- •basal FSH < 10 IU/L
排除标准
- •previous IVF or ICSI, hyperprolactinemia, hyperthyroidism, hypothyroidism, uterine abnormality, severe endometriosis
- •only one ovary
研究组 & 干预措施
1
GnRH antagonist "ganirelix" 0.25 mg fromm 6th ovarian stimulation
干预措施: ganirelix (Drug)
2
GnRH agonist, suprefact, stimulation with a standard long protocol
干预措施: suprefact (Drug)
结局指标
主要结局
pregnancy rate
时间窗: 2weeks
次要结局
- ovarian stimulation(10days)