Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Growth Hormone Baseline
研究概览
简要总结
: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.
Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.
详细描述
Preliminary measurements:
Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.
Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 9 Years 至 17 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy boys (n=40)
- •Physically active, defined as a minimum of 2 years experience in a sports club
- •Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
- •No previous experience of structured resistance training
排除标准
- •Chronic diseases that affect full participation
- •Injuries that limit full participation
结局指标
主要结局
Growth Hormone Baseline
时间窗: Baseline testing before the exercise intervention (Pre values)
Blood Concentration of Growth Hormone
Change from Baseline Growth Hormone 30 minutes post exercise
时间窗: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood Concentration of Growth Hormone
Change from Baseline Insulin-like Growth Factor-1 Post exercise
时间窗: Right after the completion of the exercise intervention (Post values)
Blood concentration of Insulin-like Growth Factor-1
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
时间窗: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Insulin-like Growth Factor-1
Change from Baseline Growth Hormone Post exercise
时间窗: Right after the completion of the exercise intervention (Post values)
Blood Concentration of Growth Hormone
Change from Baseline Growth Hormone 15 minutes post exercise
时间窗: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood Concentration of Growth Hormone
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
时间窗: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Insulin-like Growth Factor-1
Insulin-like Growth Factor-1 Baseline
时间窗: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Insulin-like Growth Factor-1
次要结局
- Testosterone Baseline(Baseline testing before the exercise intervention (Pre values))
- Change from Baseline Testosterone Post Exercise(Right after the completion of the exercise intervention (Post values))
- Change from Baseline Interleukin-6 15 minutes Post Exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Interleukin-1 alpha Baseline(Baseline testing before the exercise intervention (Pre values))
- Sex Hormone Binding Globulin Baseline(Baseline testing before the exercise intervention (Pre values))
- Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
- Change from Baseline Cortisol 30 minutes Post exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
- Interleukin-6 Baseline(Baseline testing before the exercise intervention (Pre values))
- Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
- Change from Baseline Baseline Sex Hormone Binding Post Exercise(Right after the completion of the exercise intervention (Post values))
- Cortisol Baseline(Baseline testing before the exercise intervention (Pre values))
- Change from Baseline Cortisol Post exercise(Right after the completion of the exercise intervention (Post values))
- Change from Baseline Testosterone 30 minutes Post Exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
- Tumor Necrosis Factor alpha Baseline(Baseline testing before the exercise intervention (Pre values))
- Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Change from Baseline Cortisol 15 minutes Post exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Change from Baseline Testosterone 15 minutes Post Exercise(15 minutes after the completion of the exercise intervention (Post-15 values))
- Change from Baseline Interleukin-1 alpha Post Exercise(Right after the completion of the exercise intervention (Post values))
- Change from Baseline Tumor Necrosis Factor alpha Post Exercise(Right after the completion of the exercise intervention (Post values))
- Change from Baseline Interleukin-6 Post Exercise(Right after the completion of the exercise intervention (Post values))
- Change from Baseline Interleukin-6 30 minutes Post Exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
- Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise(30 minutes after the completion of the exercise intervention (Post-30 values))
研究者
Apostolos Theos
Associate Professor
Umeå University