BRown Fat Activity Measurement With Infrared imaginG tHermography and Thermogenesis - the BRIGHT Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- Temperature at cervical-supraclavicular region
研究概览
简要总结
The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.
The infrared (IR) energy flux from activated BAT can be accurately imaged and quantified using an IR imaging device, and that this IR energy output may be correlated to the increased energy expenditure quantified by the whole body calorimeter.
详细描述
The recent rediscovery of functional brown adipose tissue (BAT) in healthy adults has opened up the exciting possibility of manipulating BAT for obesity management, and it is imperative to develop BAT imaging modalities that are non-invasive and safe for repeated use. Given that heat is a specific end-product of uncoupling protein-1 (UCP-1)-mediated BAT, this study examines whether surface body temperature assessed using infrared (IR) thermography can be a non-invasive measure to accurately and precisely predict brown adipose tissue (BAT) activation upon cold stimulation, which involves verifying an semi-automated method for characterizing thermal images. In addition, this study also aims to validate the use of a whole-body calorimeter to pick up changes in energy expenditure upon cold-induced thermogenesis. Lean, healthy male volunteers will be recruited. Thermal imaging of cervical-supraclavicular BAT will be done using an IR camera to assess changes in BAT activation. Blood samples will also be drawn at regular intervals to track changes in serum metabolites upon BAT activation. All in all, this study hopes to provide more supporting evidence that IR thermography is a viable imaging modality that is non-invasive, safe and reproducible of studying BAT activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Ethnic Chinese
- •Age between 21 to 35 years
- •Body Mass Index 18.5 to 22.9
- •Normal resting blood pressure ~120/80 mmHg
- •Normal fasting blood glucose level <5.5 mmol/L
排除标准
- •Do not train for or partake in competitive sports
- •Do not have any major diseases
- •Not on any prescribed medication
研究组 & 干预措施
Cold air
Subjects to be seated in an airtight chamber at an ambient temperature between 16 to 20 degrees Celsius for 1 hour.
干预措施: Cold air (Other)
Cold water
Subjects to be seated in an airtight chamber at an ambient temperature of 24 degrees Celsius, with their hands and feet fully immersed in cold water for 5 minutes.
干预措施: Cold water (Other)
结局指标
主要结局
Temperature at cervical-supraclavicular region
时间窗: 45 minutes cold exposure
The temperature at the cervical-supraclavicular region following cold exposure will be determined using infrared thermal imaging.
次要结局
- Energy expenditure during cold exposure(45 minutes cold exposure)
研究者
Melvin Leow
Principal Investigator
Clinical Nutrition Research Centre, Singapore