Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate)
研究概览
简要总结
Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •10 health young (20-40 y old) and 10 health older (> 60 y old) participants
- •Men and women
排除标准
- •diabetes (fasting glucose >7.0 mmol/l and glycated hemoglobin >6.9%)
- •strenuous aerobic exercise more than three times a week
- •untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function
- •under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)
研究组 & 干预措施
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: No MCT intake with breakfast, no lunch (Dietary Supplement)
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: No MCT intake with lunch, no breakfast (Dietary Supplement)
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: 10g of Betaquik (Dietary Supplement)
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: 10g of Betaquik with low-carbs breakfast (Dietary Supplement)
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: 20g of Betaquik (Dietary Supplement)
MCT intake in young participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: 10g of Betaquik with lunch, no breakfast (Dietary Supplement)
MCT intake in older participants
Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in older participants.
Interventions:
- No MCT intake with breakfast, no lunch (i.e. CTL)
- No MCT intake with lunch, no breakfast (i.e CTL inverted)
- 10g of Betaquik with breakfast, no lunch (i.e BQ10)
- 20g of Betaquik with breakfast, no lunch (i.e BQ20)
- 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC)
- 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
干预措施: 10g of Betaquik (Dietary Supplement)
结局指标
主要结局
Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate)
时间窗: 8 hours
To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.
次要结局
- Concentration of plasma glucose(8 hours)
- Concentration of plasma insulin(8 hours)
- Concentration of plasma free fatty acids(8 hours)