Psoriasis and daily low emission phototherapy; effects on disease and vitamin D level
Completed
- Conditions
- Psoriasis10014982
- Registration Number
- NL-OMON38060
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
* Psoriasis vulgaris diagnosed by a dermatologist
* 18 years or above
* Informed consent
* Patients successfully treated with phototherapy (UVB/TL01) OR after successful local therapy and a history of good clearance after UV/exposure.
Exclusion Criteria
* Use of fumaric acid or immunosuppressants now or in the 2 months previous to inclusion.
* Active psoriatic arthritis
* History of skin cancer
* Concurrent photosensitive skin disorders
* Planned sunny holidays during the trial
* Use of tanning booths (at home or tanning studio)
* Use of vitamine D supplement
* Pregnancy or actively planning to get pregnant
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>PASI-, Skindex-29 and DLQI-scores and their differences between groups. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters:<br /><br>Difference between control group and patients undergoing the home UV-treatment<br /><br>in:<br /><br>- serum levels of 25(OH)D3<br /><br>- presence of pyrimidine dimers and/or p53-expression in epidermal cells of<br /><br>patients<br /><br>- amount of mometason ointment used<br /><br>- parameters for metabolic syndrome (HbA1c, blood pressure)</p><br>