Assessment of the Effects of Extensive Sensorimotor Training on Pain Processing
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Cortical Sensory Evoked Potentials
研究概览
简要总结
Persistent pain may lead to several alterations in the brain activity and sensory perception (i.e. pain). Around 80% of professional musicians experience prolonged episodes of musculoskeletal pain throughout their careers, a percentage that is four times higher than in the general population. With this background, the intended experiment aims at understanding the role of several biological factors associated to sensorimotor training that can lead to alteration of the brain activity and, consequently, pain processing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women Speak and understand English.
- •General exclusion criteria are:
- •Pregnancy
- •Drug addiction defined as the use of cannabis, opioids or other drugs
- •Previous neurologic or mental illnesses
- •Presence of a history of trauma or neurologic entrapment syndromes to the arm regions.
- •Lack of ability to cooperate
- •Frequent computer gamer ( > 9 hours/week)
排除标准
- 未提供
研究组 & 干预措施
Healthy musicians
Men and women aged 18-60, who must be enrolled in a music conservatory performance program or be professionally active, and must speak and understand English.
干预措施: Nerve Growth Factor (Drug)
Healthy non-musicians
Men and women aged 18-60, must speak and understand English and not have any kind of musical training.
干预措施: Nerve Growth Factor (Drug)
Musicians with chronic pain
Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months. They must be enrolled in a music conservatory performance program or be professionally active and must speak and understand English.
干预措施: Nerve Growth Factor (Drug)
Non-musicians with chronic pain
Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months. They must not have any kind of musical training and must speak and understand English.
干预措施: Nerve Growth Factor (Drug)
结局指标
主要结局
Cortical Sensory Evoked Potentials
时间窗: Changes from baseline measured at day 3 and day 8
Electrical stimulation will be elicited to record sensory evoked potentials using electroencephalography (EEG)
Motor Evoked Potentials
时间窗: Changes from baseline measured at day 3 and day 8
Transcranial magnetic stimualtion will be used to evoke motor evoked potentials (MEPs)
Pain rating
时间窗: Changes from baseline measured at day 3 and day 8
Pain on an 11-point numerical rating scale (0 = no pain, 10 = most intense pain imaginable)
Brain connectivity
时间窗: Changes from baseline measured at day 3 and day 8
Continuous electroencephalography recording will be used to explore connectivity between brain areas
次要结局
- Pressure pain thresholds(Changes from baseline measured at day 3 and day 8)
- Questionnaires(Changes from baseline measured at day 3 and day 8)
研究者
Anna M. Zamorano
Principal Investigator
Aalborg University