can blood measurement and ratio between c reactive protein and albumin before operation predict need of mechanical ventilation after operation in those patients undergoing operation other than heart surgery

Completed

Conditions: Medical and Surgical, those undergoing surgery under general anaesthesia,

Brief Summary: Inthe current context, mechanical ventilation and ICU beds are limitedbut essential resources. Mechanical ventilation in thepost-operative period adds to the morbidityand mortality of surgical patients and incurs extrastress on the patient, family and economic burden on the hospital.Hence, pre-operative prediction contributes to adequate optimisationand effective utilisation. But,unfortunately, the literature only provides us with predictors formechanical ventilation in a very limited set of patients. Therefore,we experience a limitation in pre-operative optimisation, patient andfamily counselling and appropriate distribution of availableresources.

Peri-operativeinflammation is a state of high demand. Low albumin is a sign of poornutritional status. Additionally, serum albumin being a negativeacute phase reactant, the level is usually low in patients withheightened inflammation. CRP being a positive acute phase reactant,its level is usually raised in cases of any inflammation or anyinfections. So, the CRP/Albumin ratio gives us a combined healthstatus of a patient. Further, CRP/Albumin ratio has been widelyproven as a prognostic indicator and mortality predictor in patientswith various malignancies and severe sepsis.

We,therefore hypothesise that patients with high pre-operativeCRP/Albumin ratio will require mechanical ventilationpost-operatively.

Recruitment & Eligibility

Inclusion Criteria

patients undergoing elective and emergency surgery under general anaesthesia.

Exclusion Criteria

those patients who are on mechanical ventilation before surgery.

Primary Outcome Measures

Name	Time	Method
need for mechanical ventilation in the postoperative period	till hospital discharge

Secondary Outcome Measures

Name	Time	Method
intraoperative need for vasopressors, amount of blood loss	intraoperative period

Locations (1): All india institute of medical sciences
🇮🇳
Khordha, ORISSA, India
All india institute of medical sciences
🇮🇳Khordha, ORISSA, India
Vaishakh Tharavath
Principal investigator
7736767667
vaishakh4154@gmail.com