The Effects of Different Flow Settings on Lung Impedance
- Conditions
- Healthy
- Interventions
- Device: High-flow nasal cannula device with flow setting at 40 L/min or higher
- Registration Number
- NCT06228703
- Lead Sponsor
- Rush University Medical Center
- Brief Summary
This prospective, randomized crossover trial will enroll adult healthy volunteers. Initially, the subject's peak inspiratory flow will be measured using a mask connected with a respiratory monitor. Subsequently, the volunteers will undergo HFNC treatment at different flow settings while their peak inspiratory flow will be continuously monitored. The primary outcome of this study is the lung aeration with different flow settings. Secondary outcomes include the lung aeration with different devices, subject's comfort at different flow settings, and the correlation between the subject's peak inspiratory flow measured by HFNC and by a mask connected with a respiratory monitor.
- Detailed Description
Background: High-flow nasal cannula (HFNC) is a device that can reduce the work of breathing (WOB) and improve oxygenation by providing a flow that matches or exceeds patient's peak inspiratory flow during tidal breathing. Despite its widespread use, there remains a lack of consensus regarding the optimal flow settings. Two new HFNC devices that can provide information regarding patient's peak tidal inspiratory flow breath by breath are recently available, which might help guide set and titrate the flow settings. This study aims to investigate the effects of different flow settings on lung impedance in a cohort of healthy volunteers by using the two new HFNC devices.
Methods: This prospective, randomized crossover trial will enroll adult healthy volunteers. Initially, the subject's peak inspiratory flow will be measured using a mask connected with a respiratory monitor. Subsequently, the volunteers will undergo HFNC treatment at different flow settings while their peak inspiratory flow will be continuously monitored. The primary outcome of this study is the lung aeration with different flow settings. Secondary outcomes include the lung aeration with different devices, subject's comfort at different flow settings, and the correlation between the subject's peak inspiratory flow measured by HFNC and by a mask connected with a respiratory monitor.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
- Healthy volunteers between 21-65 years old
- Chronic pulmonary diseases, including COPD, interstitial lung disease, cystic fibrosis, etc.
- Uncontrolled asthma;
- Pregnancy
- Subjects who have cold/flu symptoms (sore throat, runny nose, fever, chills, coughing)
- Nose abnormalities that can affect the functionality of the nasal prongs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Airvo 3 high-flow nasal cannula device with flow set at 60 L/min High-flow nasal cannula device with flow setting at 40 L/min or higher Airvo 3 will be used with the flow set at 60 L/min Airvo 3 high-flow nasal cannula device with flow set at 40 L/min High-flow nasal cannula device with flow setting at 40 L/min or higher Airvo 3 will be used with the flow set at 40 L/min HFT 750 high-flow nasal cannula device with flow set at 40 L/min High-flow nasal cannula device with flow setting at 40 L/min or higher HFT 750 will be used with the flow set at 40 L/min HFT 750 high-flow nasal cannula device with flow set at 60 L/min High-flow nasal cannula device with flow setting at 40 L/min or higher HFT 750 will be used with the flow set at 60 L/min
- Primary Outcome Measures
Name Time Method Lung aeration assessed by Electrical impedance tomography Up to 4 hours The distribution of air in different lung regions
- Secondary Outcome Measures
Name Time Method respiratory rate Up to 4 hours respiratory rates are counted by the investigator for a minute and will be reported as breaths per minute
subject's comfort level Up to 4 hours Comfort level reported by participants using a visual numerical scale ranging between 0 (extreme discomfort) and 10 (very comfortable) at the end of each flow setting
Trial Locations
- Locations (1)
Rush University
🇺🇸Forest Park, Illinois, United States