CLE and OCT in diagnosing ILD, a comparison with imaging and pathology.

Completed

• Conditions: ILD Interstitial lung disease; 10024967

• Registration Number: NL-OMON42794
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- *18 years of age
- Supected ILD and referred for diagnostic bronchoscopic procedure with cryobiopsy

Exclusion Criteria

- Smoked in the last 6 months - Inability and willingness to provide informed consent
- Inability to comply with the study protocol

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- To describe and develop visual descriptive image criteria for pCLE images of<br /><br>the alveolar compartment in ILD<br /><br>- To describe and develop visual descriptive image criteria for pCLE images of<br /><br>airway wall mucosa in ILD<br /><br>- To obtain quantitative measures of the alveolar compartment in ILD by pCLE<br /><br>imaging (cellularity, fluorescence, size of opening alveolar duct (µm))<br /><br>- To develop descriptive image criteria and a classification of pOCT images of<br /><br>the alveolar compartment in ILD<br /><br>- To obtain quantitative measures of the alveolar compartment in ILD by pOCT<br /><br>imaging (size of alveolar duct openings, fiber thickness)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Assessing procedure-related adverse events of pCLE and pOCT<br /><br>- Assessing technical feasibility of pCLE and pOCT<br /><br>- To develop an CLE and OCT image atlas for sarcoidosis in mucosa and the<br /><br>alveolar compartment<br /><br>- To conduct exploratory breathprints from ILD patients by electronic nose, for<br /><br>the purpose of building a breathcloud</p><br>