A randomized controlled pilot and feasibility study of multimodal agility-based exercise training versus strength and endurance training to improve Multiple Sclerosis-related fatigue and fatigability during inpatient rehabilitatio

Phase 1

• Conditions: G35; Multiple sclerosis

• Registration Number: DRKS00023943
• Lead Sponsor: eurologisches Rehabilitationszentrum Godeshöhe e.V.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-23
• Study Completion: 2023-01-12
• Results First Posted: 2023-10-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

EDSS (Expanded Disability Status Scale): =5.0
-FSMC total score: =53
-MS phenotype: relapsing-remitting, secondary-progressive
-Written informed consent

Exclusion Criteria

-Unable to attend water therapy
-Comorbidities that prevent attending study therapies
-German language skills that interfere with understanding of testing and instructions
-Current fatigue medication (Amantadin, Modafinil) started <3 months ago

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fatigue <br>1. Würzburger Erschöpfungsinventar bei Multipler Sklerose (WEIMuS) [Timepoints: admission, discharge, one, four and 12 weeks after discharge]<br>2. Fatigue Scale for Motor and Cognitive Functions (FSMC) [Timepoints: admission, discharge, one, four and 12 weeks after discharge]