A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL)

Phase 3

Completed

• Conditions: Hodgkin's Lymphoma
• Interventions: Drug: Panobinostat; Drug: Placebo

• Registration Number: NCT01034163
• Lead Sponsor: Novartis Pharmaceuticals

Brief Summary

The primary objective was to provide drug to ongoing patients who were receiving panobinostat and to characterize the safety and tolerability of panobinostat in patients with HL after achieving a complete response following autologous hematopoietic stem cell transplant (AHSCT) with high dose chemotherapy (HDT). Primary objective as stated above reflects a change from the original protocol as of an amendment. The original objective was no longer feasible with only 41 of 367 patients randomized after the study was halted due to poor recruitment. An amendment was written to allow patients on panobinostat to continue their treatment until discontinuation/completion criteria were met (patients were unblinded). Therefore, the study was completed as per this amendment. No secondary objectives were included for this trial from the amendment; this was a change from the original protocol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-12-15
• Study First Submitted QC: 2009-12-16
• Study First Posted: 2009-12-17
• Study Start: 2010-06
• Primary Completion: 2012-05
• Study Completion: 2012-05
• Results First Submitted: 2016-03-01
• Status Verified: 2016-05
• Results First Submitted QC: 2016-05-27
• Last Update Submitted: 2016-05-27
• Results First Posted: 2016-07-07
• Last Update Posted: 2016-07-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

1. Patient age is greater than or equal to 18 years

2. Patient has a history of histologically confirmed classical HL (i.e. Nodular sclerosing (NSHL), Mixed-cellularity (MCHL), Lymphocyte-rich (LRHL), Lymphocyte depleted (LDHL))

3. Patient has achieved a complete response by CT/MRI scan within 9 weeks (± 1 week) from the day of their first autologous peripheral blood/ bone marrow stem cell transfusion (AHSCT) following HDT. Complete response is defined as:

   Normalization of all nodes and lesions compared to pre-transplant scan performed prior to salvage therapy for relapse. Any residual abnormal masses on the post transplant CT/MRI must be metabolically inactive on a PET scan.

4. Patient has at least one of the following factors that places them at risk for relapse:

   • Primary refractory disease (including relapse in ≤ 3 months of completion of 1st line treatment)
   • First relapse >3 but <12 months from last dose of 1st line treatment
   • Multiple relapses (prior to transplant)
   • Stage III/IV disease (at relapse, prior to transplant)
   • Hemoglobin <10.5 gm/dL (at relapse, prior to transplant)

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Exclusion Criteria

Patient has been treated with allogeneic transplant 2. Patient has received any anti-lymphoma therapy after AHSCT including but not limited to:

• chemotherapy prior to start of study
• biologic immunotherapy including monoclonal antibodies or experimental therapy prior to start of study
• radiation therapy 3. Patient has not recovered from reversible toxicity due to any prior therapies (e.g. returned to baseline or Grade ≤1) except for hematological laboratory parameters Note: Patient does not meet this criteria if the toxicity is stable and irreversible, and there is no evidence that panobinostat causes a similar toxicity 4. Patient has received prior treatment with DAC inhibitors including panobinostat

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Panobinostat (PAN)	Panobinostat	Participants received 45 mg orally 3 times a week (TIW), every other week (QOW),
Placebo	Placebo	Participants received matching placebo to PAN TIW, QOW.

Primary Outcome Measures

Name	Time	Method
Number of Participants With Adverse Events	23 months	Safety monitoring was conducted throughout the study.

Trial Locations

Locations (14)

Novartis Investigative Site; 🇸🇬 Singapore, Singapore

Mary Babb Randolph Cancer Center; 🇺🇸 Morgantown, West Virginia, United States

Northwestern University Oncology; 🇺🇸 Chicago, Illinois, United States

Georgia Health Sciences University Medical College of Georgia; 🇺🇸 Augusta, Georgia, United States

Dana-Farber Cancer Institute Dana-Farber Cancer Institute; 🇺🇸 Boston, Massachusetts, United States

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

University of California at Los Angeles; 🇺🇸 Los Angeles, California, United States

Indiana University; 🇺🇸 Indianapolis, Indiana, United States

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States

Medical University of South Carolina Oncology; 🇺🇸 Charleston, South Carolina, United States

Vanderbilt University Medical Center Vanderbilt Clinic - Oncology; 🇺🇸 Nashville, Tennessee, United States

Mayo Clinic - Rochester Hematology/Oncology Dept.; 🇺🇸 Rochester, Minnesota, United States

Medical College of Wisconsin Oncology; 🇺🇸 Milwaukee, Wisconsin, United States

Cedars Sinai Medical Center; 🇺🇸 Los Angeles, California, United States