Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

Completed

• Conditions: Major Depressive Disorder; Dysthymic Disorder; Alcohol-Related Disorders; Depressive Disorder; Alcoholism
• Interventions: Behavioral: Cognitive Behavioral Analysis System of Psychotherapy

• Registration Number: NCT01528748
• Lead Sponsor: University of Virginia

Brief Summary

This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.

Detailed Description

This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.

Study Timeline

• Study Start: 2011-04
• Study First Submitted: 2012-02-04
• Study First Submitted QC: 2012-02-04
• Study First Posted: 2012-02-08
• Primary Completion: 2015-12
• Study Completion: 2018-07
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-15
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years
• Clinical diagnosis of alcohol dependence during the last thirty days
• Interest in changing one's drinking and alleviating depressive symptoms

Exclusion Criteria

• Please call study site for additional information

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chronically Depressed, Alcohol Dependent	Cognitive Behavioral Analysis System of Psychotherapy	Participants who have been formally diagnosed with a clinical diagnosis of Chronic Depression and Alcohol Dependence.

Primary Outcome Measures

Name	Time	Method
Depression Rating	Baseline and 20 weeks	Change in depression rating scale over time.
Drinking behavior	Baseline and 20 weeks	Change in number of drinks consumed per day over time.

Trial Locations

Locations (1)

University of Virginia Center for Addiction Research & Education (UVa CARE); 🇺🇸 Charlottesville, Virginia, United States