Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depressive Disorder
- Sponsor
- University of Virginia
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Depression Rating
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.
Detailed Description
This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.
Investigators
Jennifer Kim Penberthy
Associate Professor, School of Medicine
University of Virginia
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years
- •Clinical diagnosis of alcohol dependence during the last thirty days
- •Interest in changing one's drinking and alleviating depressive symptoms
Exclusion Criteria
- •Please call study site for additional information
Outcomes
Primary Outcomes
Depression Rating
Time Frame: Baseline and 20 weeks
Change in depression rating scale over time.
Drinking behavior
Time Frame: Baseline and 20 weeks
Change in number of drinks consumed per day over time.