Low-dose Computed Tomography Screening for Lung Cancer in Relatives With Family History of Lung Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,102
- 主要终点
- Number of participants with lung cancer detected by low dose computed tomography
研究概览
简要总结
Screening with the use of low-dose computed tomography (LDCT) reduces mortality from lung cancer. Relatives with family history of lung cancer are at increased risk of lung cancer compared to those without a family history in pooled analysis. A prospective trial using LDCT of lung to screen the relatives with family history of lung cancer is needed.
详细描述
Investigators invited participants with family history to join in this study under the criteria of (1) relatives of the lung cancer patients; (2) age older than 55 years old or age older than the age of onset of lung cancer proband if the family members were less than 55 years old; (3) compulsory signing the consent agreement after understanding the purpose of study and the exposure of radiation. The participants with (1) proved lung cancer either with or without treatment, (2) presence of hemoptysis or history of remarkable lung fibrosis, (3) any other cancer history or (4) chest CT examination within one year would be excluded from the study.
The study was planned to enroll 1000 participants from simplex families and 500 participants from multiplex families for lung LDCT screening. Multiplex family was defined as two or more family members with lung cancers, and simplex family as one family member with lung cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •relatives of the lung cancer patients;
- •age older than 55 years old or age older than the age of onset of lung cancer proband if the family members were less than 55 years old;
- •compulsory signing the consent agreement after understanding the purpose of study and the exposure of radiation.
排除标准
- •proved lung cancer either with or without treatment,
- •presence of hemoptysis or history of remarkable lung fibrosis,
- •any other cancer history or
- •chest CT examination within one year
研究组 & 干预措施
Low dose computed tomography
All the Low dose computed tomography of lung was performed with 64 slices multidetectors CT in single hold breath covering entire lung. The protocol of scanning parameters (120KVp, 40-80 mA, 1.25 mm or less in thickness) was standardized. The raw data would be reconstructed to axial images (3 mm thickness and interval) and coronal images (3 mm thickness and interval). The scan should be finished in a single breath (15-20 second) from the thoracic inlet to adrenal glands.
干预措施: low dose computed tomography (Device)
结局指标
主要结局
Number of participants with lung cancer detected by low dose computed tomography
时间窗: three years
次要结局
- Detection rate of early lung cancer(three years)
研究者
Kuo-Husan Hsu
Attending physician
Taichung Veterans General Hospital