Difference in stomach pH-values of constant enteral nutrition and constant parenteral nutrition under standardized enteral supply with a proton pump inhibitor.

• Conditions: K25; K26; Gastric ulcer; Duodenal ulcer

• Registration Number: DRKS00024513
• Lead Sponsor: niversitätsklinik für Anästhesiologie, operative Intensivmedizin, Rettungsmedizin, Schmerztherapie, Campus OWL, Klinikum Herford AöR

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-24
• Study Completion: 2022-04-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

1. intensive care patient (fasted for at least 8 hours)
2. 18 years or older
3. (planned) constant enteral feeding (group A)
or
(planned) constant parenteral feeding (group B)
4. planned, oral stress ulcer prophylaxis with the proton pump inhibitor esomeprazole (according to SOPs)

Exclusion Criteria

1.Acute gastrointestinal bleeding with additional spontaneous drop in mean arterial blood pressure of at least 20 mmHg or start of vasopressor therapy or 20% increase of vasopressors given or decrease of hemoglobin serum concentration of at least 3 g/dl without other causes or administration of 2 or more erythrocyte concentrates.

2. Patients suffering Gastroenteritis or Ileus-symptomatology at the time of study enrolment.

3. Pregnant or breast feeding women

4. Significant gastric emptying retardation with reflux via a persisting stomach tube of more than 750 ml/24h at the time of study enrolment.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stomach pH of intensive care patients during enteral feeding in comparison to stomach pH of intensive care patients during parenteral feeding.

Secondary Outcome Measures

Name	Time	Method
Stomach pH of intensive care patients during enteral feeding who took gastric acid inhibiting drugs at least 3 days before study inclusion in comparison to stomach pH of intensive care patients during enteral feeding who did not take gastric acid inhibiting drugs at least 3 days before study inclusion.<br><br>Stomach pH of intensive care patients during parenteral feeding who took gastric acid inhibiting drugs at least 3 days before study inclusion in comparison to stomach pH of intensive care patients during parenteral feeding who did not take gastric acid inhibiting drugs at least 3 days before study inclusion.<br><br>