Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
- Conditions
- Coronary Heart DiseasePeriodontitis
- Interventions
- Procedure: non-surgical periodontal treatment
- Registration Number
- NCT04305171
- Lead Sponsor
- Mahidol University
- Brief Summary
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
- Detailed Description
CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
- non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months)
- had at least 14 natural teeth excluding third molars
- received anticoagulant drugs
- had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
- pregnancy or lactation
- presence or history of other infections
- periodontal treatment within 6 months
- tooth extractions within 2 months prior to the study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description non-coronary heart disease patients without periodontitis non-surgical periodontal treatment Non-periodontitis classified as having PD ≤ 3 mm. non-coronary heart disease patients with periodontitis non-surgical periodontal treatment Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. coronary heart disease patients with periodontitis non-surgical periodontal treatment Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. coronary heart disease patients without periodontitisHD non-surgical periodontal treatment Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Non-periodontitis classified as having PD ≤ 3 mm.
- Primary Outcome Measures
Name Time Method change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment change in plasma fibrinogen level (pg/mL)
change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment change in C-reactive protein level (mg/L)
change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment change in plasma fibrinogen level (pg/mL)
change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment change in C-reactive protein level (mg/L)
change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment change in activator inhibitor 1 level (pg/mL)
change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment change in activator inhibitor 1 level (pg/mL)
- Secondary Outcome Measures
Name Time Method change of bleeding on probing between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment percetage of sites with bleeding on probing
change of pocket depth between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment Depth of periodontal pocket in millimeters
change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment percetage of sites with bleeding on probing
change of clinical attachment level between baseline and 6 months after non-surgical periodontal treatment 6 months after non-surgical periodontal treatment Level of clinical attachment in millimeters
change of pocket depth between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment Depth of periodontal pocket in millimeters
change of clinical attachment level between baseline and 3 months after non-surgical periodontal treatment 3 months after non-surgical periodontal treatment Level of clinical attachment in millimeters
Trial Locations
- Locations (3)
Department of Medicine, Rajavithi Hospital
🇹🇭Ratchathewi, Bangkok, Thailand
Mahidol University Faculty of Dentistry
🇹🇭Ratchathewi, Bangkok, Thailand
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University
🇹🇭Ratchathewi, Bangkok, Thailand