Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 3
- 主要终点
- change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment
研究概览
简要总结
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
详细描述
CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months)
- •had at least 14 natural teeth excluding third molars
排除标准
- •received anticoagulant drugs
- •had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
- •pregnancy or lactation
- •presence or history of other infections
- •periodontal treatment within 6 months
- •tooth extractions within 2 months prior to the study.
结局指标
主要结局
change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment
时间窗: 3 months after non-surgical periodontal treatment
change in plasma fibrinogen level (pg/mL)
change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment
时间窗: 3 months after non-surgical periodontal treatment
change in C-reactive protein level (mg/L)
change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment
时间窗: 6 months after non-surgical periodontal treatment
change in plasma fibrinogen level (pg/mL)
change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment
时间窗: 6 months after non-surgical periodontal treatment
change in C-reactive protein level (mg/L)
change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment
时间窗: 3 months after non-surgical periodontal treatment
change in activator inhibitor 1 level (pg/mL)
change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment
时间窗: 6 months after non-surgical periodontal treatment
change in activator inhibitor 1 level (pg/mL)
次要结局
- change of bleeding on probing between baseline and 6 months after non-surgical periodontal treatment(6 months after non-surgical periodontal treatment)
- change of pocket depth between baseline and 6 months after non-surgical periodontal treatment(6 months after non-surgical periodontal treatment)
- change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment(3 months after non-surgical periodontal treatment)
- change of clinical attachment level between baseline and 6 months after non-surgical periodontal treatment(6 months after non-surgical periodontal treatment)
- change of pocket depth between baseline and 3 months after non-surgical periodontal treatment(3 months after non-surgical periodontal treatment)
- change of clinical attachment level between baseline and 3 months after non-surgical periodontal treatment(3 months after non-surgical periodontal treatment)