Prediction of Lymphatic Metastasis in Esophageal Cancer by CT Radiomics

Completed

• Conditions: Esophagus Cancer
• Interventions: Procedure: preoperative enhanced chest CT examination

• Registration Number: NCT03237130
• Lead Sponsor: Peking University Cancer Hospital & Institute

Brief Summary

This study proposes to establish a CT radiomics-based prediction model for identifying metastasis lymph nodes in esophageal cancer.

Detailed Description

This study proposes to establish an image feature extraction and selection method for identifying lymph node metastasis of esophageal cancer.The study will consider the relationship between the main lesion and the suspected lymph node, extract association characteristics in order to improve the sensitivity and specificity of the CT radiomics-based prediction model for identifying metastasis lymph nodes. The study includes the construction of CT radiomics-based prediction model and the validation of the prediction model.

Study Timeline

• Study Start: 2017-02-15
• Study First Submitted: 2017-07-31
• Study First Submitted QC: 2017-07-31
• Study First Posted: 2017-08-02
• Primary Completion: 2019-11-07
• Study Completion: 2020-05-15
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-31
• Last Update Posted: 2021-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 133

Inclusion Criteria

• pathologically proven esophageal cancer
• scheduled to preoperative enhanced chest CT and undergo surgery
• sign the patient informed consent

Exclusion Criteria

• failed to receive preoperative enhanced chest CT or undergo surgery
• inavailable pathological results for local lymph node status
• inquality of CT images for feature extraction
• patient quit

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
preoperative enhanced chest CT	preoperative enhanced chest CT examination	The cohort contains patients with preoperative therapies and patients without preoperative therapies. Each patient receives regular preoperative enhanced chest CT; for patients with preoperative therapies, they usually undergo twice enhanced chest CT examination at before and after preoperative therapies, the CT images after preoperative therapies will be used for analysis

Primary Outcome Measures

Name	Time	Method
pathological local lymph node status	Pathologic evaluation will be performed for each patient within 1 week after surgery	pathological lymph node status is defined as lymph node metastasis exist or not

Trial Locations

Locations (1)

Beijing Cancer Hospital; 🇨🇳 Beijing, Beijing, China