Impact of Sarcopenia Index on Postoperative Pulmonary Complication in Elderly Patients Undergoing OPCAB

Completed

• Conditions: Coronary Artery Occlusive Disease

• Registration Number: NCT04654663
• Lead Sponsor: Yonsei University

Brief Summary

Retrospective data collection. The aim of this study is to determine the effect of preoperative sarcopenia index on postoperative pulmonary complications in elderly patients undergoing off-pump coronary artery bypass graft surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-11-29
• Study First Submitted QC: 2020-11-29
• Study First Posted: 2020-12-04
• Study Start: 2020-12-07
• Primary Completion: 2021-01-15
• Study Completion: 2021-01-15
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-27
• Last Update Posted: 2021-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 605

Inclusion Criteria

• Patients who were 65 years of age or older at the time of surgery(off-pump coronary artery bypass graft surgery)
• serum cystatin C and creatinine test results were valid within one week before surgery

Exclusion Criteria

• Patients with chronic renal failure (estimated glomerular filtration rate less than 60)
• Patients with acute kidney injury
• Patients with respiratory tract infection within 1 month before surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
postoperative pulmonary complications : prolonged ventilation	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient had prolonged post-operative pulmonary ventilation \> 24.0 hours. The hours of postoperative ventilation time include OR exit until extubation, plus any additional hours following reintubation.
postoperative pulmonary complications : pneumonia	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	CXR with at least one of the following: infiltrate, consolidation, cavitation;plus at least one of the following: fever \>38 °C with no other cause, white cell count \<4 or\>12\*109 litre-1, \>70 yr of age with altered mental status with no other cause;-plus at least two of the following: new purulent/ changed sputum, increased secretions/suctioning, new/worse cough/dyspnoea/tachypnoea, rales/ bronchial breath sounds, worsening gas exchange.
postoperative pulmonary complications : reintubation	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient was intubated for the first time after leaving the OR from the initial procedure, or re-intubated during the hospital stay after the initial extubation.

Secondary Outcome Measures

Name	Time	Method
postoperative complications : Reoperation due to bleeding/tamponade	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient was reexplored for mediastinal bleeding with or without tamponade either in the ICU or returned to the operating room.
postoperative complications : Renal failure	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient had acute renal failure or worsening renal function resulting in ONE OR BOTH of the following: 1. Increase in serum creatinine level 3.0 x greater than baseline, or serum creatinine level ≥4 mg/dL , Acute rise must be at least 0.5 mg/dl 2. A new requirement for dialysis postoperatively.
postoperative complications : Delirium	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient experienced postoperative delirium from OR Exit to ICU discharge.
postoperative complications : Mortality	After discharge from the hospital, but before the end of the 30th postoperative day.	all deaths, regardless of cause, occurring after discharge from the hospital, but before the end of the 30th postoperative day.
postoperative complications : Permanent stroke	During the hospitalization for surgery. This includes the entire postoperative period up to discharge, even if over 30 days.	Indicate whether the patient has a postoperative stroke (i.e., any confirmed neurological deficit of abrupt onset caused by a disturbance in blood supply to the brain) that was confirmed on imaging or did not resolve within 24 hours.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of