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Clinical Trials/NCT06107257
NCT06107257
Recruiting
Not Applicable

Cardiogenic Acute Pulmonary Edema in Subjects Over 75 Years Old: Impact of Non-invasive Ventilation on Mortality

University Hospital, Strasbourg, France1 site in 1 country200 target enrollmentFebruary 1, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiogenic Pulmonary Edema
Sponsor
University Hospital, Strasbourg, France
Enrollment
200
Locations
1
Primary Endpoint
Survival Analysis
Status
Recruiting
Last Updated
2 years ago

Overview

Brief Summary

People aged over 75 represent almost 10% of the general population, and 12 to 14% of patients consulting emergency departments. Cardiogenic acute pulmonary edema (APO) is a very common reason for admission to the emergency room. The effectiveness of non-invasive ventilation (NIV) has been demonstrated during the management of PAO and would allow, compared to medical treatment alone, a more rapid improvement in clinical and gasometric parameters as well as a reduction in the need for ventilation. orotracheal intubation. On the other hand, the impact of NIV on mortality in cardiogenic PAO seems poorly defined, with lower levels of scientific evidence regarding a possible benefit in terms of survival, particularly in the elderly population.

The objective of this study is to determine whether the use of NIV in cardiogenic PAO in elderly subjects admitted to the emergency room of Strasbourg University Hospital would have an impact in terms of mortality up to 6 months compared to medical treatment alone.

Registry
clinicaltrials.gov
Start Date
February 1, 2023
End Date
December 31, 2023
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
University Hospital, Strasbourg, France
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Adult subject (\> 75 years old)
  • Admission to the NHC emergency room between January 1, 2021 and October 31, 2021
  • Diagnosis of cardiogenic PAO
  • Indication of NIV according to current recommendations
  • Subject not opposing the reuse of their data for scientific research purposes.

Exclusion Criteria

  • Subject having expressed his opposition to the reuse of his data for scientific research purposes.
  • Presence of an absolute contraindication to NIV
  • Respiratory distress due to pneumonia or other diagnosis
  • RT-PCR Sars Cov 2 positive in emergency

Outcomes

Primary Outcomes

Survival Analysis

Time Frame: 6 months after cardiogenic acute pulmonary edema

Study Sites (1)

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